Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies
Abstract Polycystic ovary syndrome (PCOS), the most common endocrine disease in women of reproductive age, severely impacts female fertility due to chronic anovulation and currently lacks effective clinical treatment strategies. The extracellular matrix (ECM) is a three-dimensional, non-cellular fra...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Biological Engineering |
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| Online Access: | https://doi.org/10.1186/s13036-025-00533-9 |
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| author | Yunxi Liu Jialei Zhu Yingli Yang Zhengyun Chen Yong Zhou Weidong Fei Xian Zhang Yongquan Zheng |
| author_facet | Yunxi Liu Jialei Zhu Yingli Yang Zhengyun Chen Yong Zhou Weidong Fei Xian Zhang Yongquan Zheng |
| author_sort | Yunxi Liu |
| collection | DOAJ |
| description | Abstract Polycystic ovary syndrome (PCOS), the most common endocrine disease in women of reproductive age, severely impacts female fertility due to chronic anovulation and currently lacks effective clinical treatment strategies. The extracellular matrix (ECM) is a three-dimensional, non-cellular framework comprising molecules such as collagens, elastin, and laminin, which support the ovarian structure and provide extracellular signals to cells. Changes in ECM localization and composition can disturb local biochemical pathways, impair folliculogenesis, and reduce the fertility of women. This paper explores innovative therapeutic approaches for PCOS by investigating the mechanisms underlying PCOS pathogenesis due to ECM dysregulation. This includes ECM deposition-induced inflammation and fibrosis, impaired ECM degradation, altered mechanical forces in ECM remodeling, and disrupted interactions between granulosa cells and the ECM. In the second part, we present therapeutic strategies informed by these pathogenic mechanisms, integrating insights from basic and clinical research. More importantly, this paper introduces innovative therapies for POCS that regulate ECM. These therapeutic strategies represent future development directions. In the final section, we summarize the advantages, potential challenges, and prospects of ECM-based treatments for improving fertility in PCOS. Overall, this review underscores the emerging significance of ECM-targeted interventions in unraveling PCOS pathophysiology and paves the way for the development of more precise and effective fertility-preserving therapies. |
| format | Article |
| id | doaj-art-3a5a2e79838d4fb0bc41373f736efc11 |
| institution | Kabale University |
| issn | 1754-1611 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj-art-3a5a2e79838d4fb0bc41373f736efc112025-08-20T03:45:32ZengBMCJournal of Biological Engineering1754-16112025-07-0119112810.1186/s13036-025-00533-9Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologiesYunxi Liu0Jialei Zhu1Yingli Yang2Zhengyun Chen3Yong Zhou4Weidong Fei5Xian Zhang6Yongquan Zheng7Women’s Hospital, Zhejiang University School of MedicineObstetrics and Gynecology Hospital of Fudan UniversityWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineAbstract Polycystic ovary syndrome (PCOS), the most common endocrine disease in women of reproductive age, severely impacts female fertility due to chronic anovulation and currently lacks effective clinical treatment strategies. The extracellular matrix (ECM) is a three-dimensional, non-cellular framework comprising molecules such as collagens, elastin, and laminin, which support the ovarian structure and provide extracellular signals to cells. Changes in ECM localization and composition can disturb local biochemical pathways, impair folliculogenesis, and reduce the fertility of women. This paper explores innovative therapeutic approaches for PCOS by investigating the mechanisms underlying PCOS pathogenesis due to ECM dysregulation. This includes ECM deposition-induced inflammation and fibrosis, impaired ECM degradation, altered mechanical forces in ECM remodeling, and disrupted interactions between granulosa cells and the ECM. In the second part, we present therapeutic strategies informed by these pathogenic mechanisms, integrating insights from basic and clinical research. More importantly, this paper introduces innovative therapies for POCS that regulate ECM. These therapeutic strategies represent future development directions. In the final section, we summarize the advantages, potential challenges, and prospects of ECM-based treatments for improving fertility in PCOS. Overall, this review underscores the emerging significance of ECM-targeted interventions in unraveling PCOS pathophysiology and paves the way for the development of more precise and effective fertility-preserving therapies.https://doi.org/10.1186/s13036-025-00533-9Polycystic ovary syndromeExtracellular matrixFollicle developmentPathogenesisTherapeutic strategies |
| spellingShingle | Yunxi Liu Jialei Zhu Yingli Yang Zhengyun Chen Yong Zhou Weidong Fei Xian Zhang Yongquan Zheng Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies Journal of Biological Engineering Polycystic ovary syndrome Extracellular matrix Follicle development Pathogenesis Therapeutic strategies |
| title | Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies |
| title_full | Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies |
| title_fullStr | Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies |
| title_full_unstemmed | Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies |
| title_short | Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies |
| title_sort | extracellular matrix dysregulation in pcos pathogenesis therapeutic strategies and innovative technologies |
| topic | Polycystic ovary syndrome Extracellular matrix Follicle development Pathogenesis Therapeutic strategies |
| url | https://doi.org/10.1186/s13036-025-00533-9 |
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