CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases

CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases

Abstract CD200 is a glycoprotein that binds with its receptor CD200R, providing immunosuppressive signals to T and NK cells. CD200 is expressed by normal stem cells and progenitors committed to B-lymphopoiesis and myeloid development. CD200 biological relevance in acute leukemias is only partially u...

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Main Authors: Laura González-Guerrero, Helena Castellet, Clara Martínez, Nuria González, Francesca Guijarro, Natalia Lloveras, Marta Pratcorona, Ignasi Gich, Pau Berenguer-Molins, Júlia Perera-Bel, Lurdes Zamora, Martí Mascaró, Antonia Sampol, Antoni Garcia-Guiñón, Susana Vives, Mar Tormo, Montserrat Arnan, Neus Villamor, Josep F. Nomdedéu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Diagnostic Pathology
Subjects:
CD200
Acute myeloid leukemia- RUNX1
CEBPA -NPM1
FLT3
Online Access:https://doi.org/10.1186/s13000-025-01655-w
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