Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon
Abstract Introduction HIV/AIDS infection continues to wreak havoc despite the many response strategies that have been put in place. Although more and more patients are receiving Antiretroviral Therapy (ART), challenges remain, including treatment efficacy and the risk of failure. This study aims to...
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Springer
2025-05-01
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| Online Access: | https://doi.org/10.1007/s44155-025-00192-7 |
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| author | Amandine Koe Ngono Godfroy Rostant Pokam Djoko Alice Ketchaji Protais Cédric Mouenbori Sawi Kelly Cynthia Fodom Tchogang Béatrice Tengoche Dorcas Kamguem Keng Stéphanie Rose Kenne Maffouo Um Bock |
| author_facet | Amandine Koe Ngono Godfroy Rostant Pokam Djoko Alice Ketchaji Protais Cédric Mouenbori Sawi Kelly Cynthia Fodom Tchogang Béatrice Tengoche Dorcas Kamguem Keng Stéphanie Rose Kenne Maffouo Um Bock |
| author_sort | Amandine Koe Ngono |
| collection | DOAJ |
| description | Abstract Introduction HIV/AIDS infection continues to wreak havoc despite the many response strategies that have been put in place. Although more and more patients are receiving Antiretroviral Therapy (ART), challenges remain, including treatment efficacy and the risk of failure. This study aims to assess the prevalence and factors associated with ART failure among people living with HIV (PLHIV) at Logbaba District Hospital. Methodology This quantitative, descriptive, and analytical study was conducted on PLHIV followed up at Logbaba between January 2021 and January 2022. Data were collected from medical records (n = 320) via a retrospective survey. Relative and absolute frequencies were calculated. Factors associated with treatment failure were analyzed using multiple logistic regression, with odds ratios, confidence intervals, and p-values. The threshold for statistical significance was set at p < 0.05. Results A total of 320 patient medical records were reviewed. Patients ranged in age from 36 to 50 years (45%). 18.1% of participants had treatment failure and 81.9% did not. Independent predictors of treatment failure were mainly in the 36–50 age group [ORa = 3.33 (95% CI 1.15–14); p = 0.030], having used modern medicine as a previous treatment [ORa = 3.35 (95% CI 1.24–12.02); p = 0.034], being on a second-line regimen (Efavirenz + Zidovudine + Lamivudine) [ORa = 4.2 (95% CI 1.40–40); p = 0.0006], having changed treatment regimen [ORa = 3.72 (95% CI 1.23–11.4); p = 0.019], as well as failure to adhere to treatment schedules [ORa = 7.48 (95% CI 2.32–74.93); p = 0.0008]. Conclusions This study highlights the critical factors associated with antiretroviral treatment failure in people living with HIV. The results underline the need for targeted interventions to improve treatment outcomes. By reinforcing patient education on the importance of adherence and personalized treatment strategies for high-risk groups, we can potentially increase the effectiveness of care. These measures are essential to strengthen the global response to the HIV/AIDS epidemic and improve the quality of life of those affected. |
| format | Article |
| id | doaj-art-3a526daadea74ebf82b283d71d193940 |
| institution | OA Journals |
| issn | 2731-0469 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
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| series | Discover Social Science and Health |
| spelling | doaj-art-3a526daadea74ebf82b283d71d1939402025-08-20T02:10:52ZengSpringerDiscover Social Science and Health2731-04692025-05-015111210.1007/s44155-025-00192-7Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, CameroonAmandine Koe Ngono0Godfroy Rostant Pokam Djoko1Alice Ketchaji2Protais Cédric Mouenbori Sawi3Kelly Cynthia Fodom Tchogang4Béatrice Tengoche5Dorcas Kamguem Keng6Stéphanie Rose Kenne Maffouo7Um Bock8Department of Public Health, School of Health Sciences of the Catholic University of Central AfricaResearch Unit of Applied Biology and Ecology, Department of Animal Biology, Faculty of Science, University of DschangDepartment of Diseases, Epidemics and Pandemics, Ministry of Public HealthResearch Unit in Biochemistry of Medicinal Plants, Food Science and Nutrition, Department of Biochemistry, Faculty of Science, University of DschangResearch Unit in Pharmacology and Physiology, Department of Animal Biology, Faculty of Science, University of DschangDepartment of Public Health, School of Health Sciences of the Catholic University of Central AfricaDepartment of Public Health, School of Health Sciences of the Catholic University of Central AfricaDepartment of Public Health, School of Health Sciences of the Catholic University of Central AfricaDepartment of Public Health, School of Health Sciences of the Catholic University of Central AfricaAbstract Introduction HIV/AIDS infection continues to wreak havoc despite the many response strategies that have been put in place. Although more and more patients are receiving Antiretroviral Therapy (ART), challenges remain, including treatment efficacy and the risk of failure. This study aims to assess the prevalence and factors associated with ART failure among people living with HIV (PLHIV) at Logbaba District Hospital. Methodology This quantitative, descriptive, and analytical study was conducted on PLHIV followed up at Logbaba between January 2021 and January 2022. Data were collected from medical records (n = 320) via a retrospective survey. Relative and absolute frequencies were calculated. Factors associated with treatment failure were analyzed using multiple logistic regression, with odds ratios, confidence intervals, and p-values. The threshold for statistical significance was set at p < 0.05. Results A total of 320 patient medical records were reviewed. Patients ranged in age from 36 to 50 years (45%). 18.1% of participants had treatment failure and 81.9% did not. Independent predictors of treatment failure were mainly in the 36–50 age group [ORa = 3.33 (95% CI 1.15–14); p = 0.030], having used modern medicine as a previous treatment [ORa = 3.35 (95% CI 1.24–12.02); p = 0.034], being on a second-line regimen (Efavirenz + Zidovudine + Lamivudine) [ORa = 4.2 (95% CI 1.40–40); p = 0.0006], having changed treatment regimen [ORa = 3.72 (95% CI 1.23–11.4); p = 0.019], as well as failure to adhere to treatment schedules [ORa = 7.48 (95% CI 2.32–74.93); p = 0.0008]. Conclusions This study highlights the critical factors associated with antiretroviral treatment failure in people living with HIV. The results underline the need for targeted interventions to improve treatment outcomes. By reinforcing patient education on the importance of adherence and personalized treatment strategies for high-risk groups, we can potentially increase the effectiveness of care. These measures are essential to strengthen the global response to the HIV/AIDS epidemic and improve the quality of life of those affected.https://doi.org/10.1007/s44155-025-00192-7Treatment failurePLHIVAssociated factorsLogbabaCameroon |
| spellingShingle | Amandine Koe Ngono Godfroy Rostant Pokam Djoko Alice Ketchaji Protais Cédric Mouenbori Sawi Kelly Cynthia Fodom Tchogang Béatrice Tengoche Dorcas Kamguem Keng Stéphanie Rose Kenne Maffouo Um Bock Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon Discover Social Science and Health Treatment failure PLHIV Associated factors Logbaba Cameroon |
| title | Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon |
| title_full | Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon |
| title_fullStr | Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon |
| title_full_unstemmed | Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon |
| title_short | Antiretroviral treatment failure and associated factors among people living with HIV at Logbaba district hospital, Cameroon |
| title_sort | antiretroviral treatment failure and associated factors among people living with hiv at logbaba district hospital cameroon |
| topic | Treatment failure PLHIV Associated factors Logbaba Cameroon |
| url | https://doi.org/10.1007/s44155-025-00192-7 |
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