Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients
Background: Acute ischemic stroke occurs when blood clots obstruct blood vessels within the brain. Platelets (Plts) are integral to the pathophysiology of stroke. This research aimed to explore the relationship between Plt quality and Plt indices in the context of acute ischemic stroke. Methods: Thi...
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Golestan University of Medical Sciences
2024-07-01
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| Series: | Medical Laboratory Journal |
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| Online Access: | http://mlj.goums.ac.ir/article-1-1650-en.pdf |
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| author | Ebrahim Mohammed Abed Ahamid Ahmed Babker Ahmed Mohamed Bakri Yousf Mohamed Nour Babiker Saad Almugadam |
| author_facet | Ebrahim Mohammed Abed Ahamid Ahmed Babker Ahmed Mohamed Bakri Yousf Mohamed Nour Babiker Saad Almugadam |
| author_sort | Ebrahim Mohammed Abed Ahamid Ahmed |
| collection | DOAJ |
| description | Background: Acute ischemic stroke occurs when blood clots obstruct blood vessels within the brain. Platelets (Plts) are integral to the pathophysiology of stroke. This research aimed to explore the relationship between Plt quality and Plt indices in the context of acute ischemic stroke.
Methods: This cross-sectional investigation involved 100 patients diagnosed with acute ischemic stroke at Kosti Teaching Hospital and Alyammama Hospitals. The diagnosis was confirmed using brain CT imaging and electrocardiography (ECG). Blood samples were collected in EDTA-containing tubes within 24 hours following the commencement of treatment and were subsequently analyzed for Plt count, mean Plt volume (MPV), Plt distribution width (PDW), and plateletcrit (PCT) utilizing a hematological analyzer. Data were analyzed using GraphPad Prism software.
Results: Platelet counts negatively correlated with PDW [r=-0.074, P=0.459; R=-0.023, P=0.815], MPV [r=-0.130, P=0.194; R=-0.081, P=0.417], and diastolic blood pressure [r= -0.023, P=0.818; R= -0.024, P=0.805]; and positively correlated with PCT [r= 0.103, P=0.308; R=0.143, P=0.155] and diastolic blood pressure [r=0.022, P=0.823; R= 0.008, P=0.932]. Moreover, PDW positively correlated with systolic blood pressure [r=0.105, P=0.298; R= 0.147, P=0.148] and diastolic blood pressure [r=0.146, P=0.145; R=0.173, P=0.084]. Based on Spearman but not Pearson correlation, PDW showed a negative correlation with PCT [r=-0.005, P=0.959; R=0.010, P=0.929].
Conclusion: The study shows a correlation between Plt count and indices in ischemic stroke patients. The research also presented evidence concerning the relationship between diastolic and systolic blood pressure and Plt counts and indices. |
| format | Article |
| id | doaj-art-3a51d4b7f65e47c69a0250f4e47484ef |
| institution | OA Journals |
| issn | 2538-4449 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Golestan University of Medical Sciences |
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| series | Medical Laboratory Journal |
| spelling | doaj-art-3a51d4b7f65e47c69a0250f4e47484ef2025-08-20T01:53:11ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492024-07-011841113Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patientsEbrahim Mohammed Abed Ahamid Ahmed0Babker Ahmed Mohamed1Bakri Yousf Mohamed Nour2Babiker Saad Almugadam3 Department of Hematology and Immunohematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wadmedani, Sudan ; Kosti Teaching Hospital, Kosti, Sudan Department of Pathology, Faculty of Medicine, Karari University, Khartoum, Sudan Department of Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wadmedani, Sudan Department of Microbiology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan Background: Acute ischemic stroke occurs when blood clots obstruct blood vessels within the brain. Platelets (Plts) are integral to the pathophysiology of stroke. This research aimed to explore the relationship between Plt quality and Plt indices in the context of acute ischemic stroke. Methods: This cross-sectional investigation involved 100 patients diagnosed with acute ischemic stroke at Kosti Teaching Hospital and Alyammama Hospitals. The diagnosis was confirmed using brain CT imaging and electrocardiography (ECG). Blood samples were collected in EDTA-containing tubes within 24 hours following the commencement of treatment and were subsequently analyzed for Plt count, mean Plt volume (MPV), Plt distribution width (PDW), and plateletcrit (PCT) utilizing a hematological analyzer. Data were analyzed using GraphPad Prism software. Results: Platelet counts negatively correlated with PDW [r=-0.074, P=0.459; R=-0.023, P=0.815], MPV [r=-0.130, P=0.194; R=-0.081, P=0.417], and diastolic blood pressure [r= -0.023, P=0.818; R= -0.024, P=0.805]; and positively correlated with PCT [r= 0.103, P=0.308; R=0.143, P=0.155] and diastolic blood pressure [r=0.022, P=0.823; R= 0.008, P=0.932]. Moreover, PDW positively correlated with systolic blood pressure [r=0.105, P=0.298; R= 0.147, P=0.148] and diastolic blood pressure [r=0.146, P=0.145; R=0.173, P=0.084]. Based on Spearman but not Pearson correlation, PDW showed a negative correlation with PCT [r=-0.005, P=0.959; R=0.010, P=0.929]. Conclusion: The study shows a correlation between Plt count and indices in ischemic stroke patients. The research also presented evidence concerning the relationship between diastolic and systolic blood pressure and Plt counts and indices.http://mlj.goums.ac.ir/article-1-1650-en.pdfplatelet countmpv 1743 aiiiporphyria cutanea tardatype iischemic stroke |
| spellingShingle | Ebrahim Mohammed Abed Ahamid Ahmed Babker Ahmed Mohamed Bakri Yousf Mohamed Nour Babiker Saad Almugadam Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients Medical Laboratory Journal platelet count mpv 1743 aiii porphyria cutanea tarda type i ischemic stroke |
| title | Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients |
| title_full | Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients |
| title_fullStr | Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients |
| title_full_unstemmed | Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients |
| title_short | Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients |
| title_sort | correlation between platelet counts mpv pdw pct and age in acute ischemic stroke patients |
| topic | platelet count mpv 1743 aiii porphyria cutanea tarda type i ischemic stroke |
| url | http://mlj.goums.ac.ir/article-1-1650-en.pdf |
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