Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis
The mechanisms that promote either resistance or susceptibility to TB disease remain insufficiently understood. Our aim was to compare the expression of cell signaling transduction receptors, CD14, TLR2, CD206, and β2 integrin LFA-1 on monocytes from patients with active TB or nonmycobacterial lung...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/851452 |
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| author | Magdalena Druszczynska Marcin Wlodarczyk Beata Janiszewska-Drobinska Grzegorz Kielnierowski Joanna Zawadzka Magdalena Kowalewicz-Kulbat Marek Fol Piotr Szpakowski Karolina Rudnicka Magdalena Chmiela Wieslawa Rudnicka |
| author_facet | Magdalena Druszczynska Marcin Wlodarczyk Beata Janiszewska-Drobinska Grzegorz Kielnierowski Joanna Zawadzka Magdalena Kowalewicz-Kulbat Marek Fol Piotr Szpakowski Karolina Rudnicka Magdalena Chmiela Wieslawa Rudnicka |
| author_sort | Magdalena Druszczynska |
| collection | DOAJ |
| description | The mechanisms that promote either resistance or susceptibility to TB disease remain insufficiently understood. Our aim was to compare the expression of cell signaling transduction receptors, CD14, TLR2, CD206, and β2 integrin LFA-1 on monocytes from patients with active TB or nonmycobacterial lung disease and healthy individuals with M.tb latency and uninfected controls to explain the background of the differences between clinical and subclinical forms of M.tb infection. A simultaneous increase in the expression of the membrane bound mCD14 receptor and LFA-1 integrin in patients with active TB may be considered a prodrome of breaking immune control by M.tb bacilli in subjects with the latent TB and absence of clinical symptoms. |
| format | Article |
| id | doaj-art-3a4b67de9d4246168a70dddfa730b121 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3a4b67de9d4246168a70dddfa730b1212025-08-20T03:55:37ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/851452851452Monocyte Signal Transduction Receptors in Active and Latent TuberculosisMagdalena Druszczynska0Marcin Wlodarczyk1Beata Janiszewska-Drobinska2Grzegorz Kielnierowski3Joanna Zawadzka4Magdalena Kowalewicz-Kulbat5Marek Fol6Piotr Szpakowski7Karolina Rudnicka8Magdalena Chmiela9Wieslawa Rudnicka10Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandRegional Specialized Hospital of Tuberculosis, Lung Diseases and Rehabilitation, Szpitalna 5, 95-080 Tuszyn, PolandRegional Specialized Hospital of Tuberculosis, Lung Diseases and Rehabilitation, Szpitalna 5, 95-080 Tuszyn, PolandRegional Specialized Hospital of Tuberculosis, Lung Diseases and Rehabilitation, Szpitalna 5, 95-080 Tuszyn, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandThe mechanisms that promote either resistance or susceptibility to TB disease remain insufficiently understood. Our aim was to compare the expression of cell signaling transduction receptors, CD14, TLR2, CD206, and β2 integrin LFA-1 on monocytes from patients with active TB or nonmycobacterial lung disease and healthy individuals with M.tb latency and uninfected controls to explain the background of the differences between clinical and subclinical forms of M.tb infection. A simultaneous increase in the expression of the membrane bound mCD14 receptor and LFA-1 integrin in patients with active TB may be considered a prodrome of breaking immune control by M.tb bacilli in subjects with the latent TB and absence of clinical symptoms.http://dx.doi.org/10.1155/2013/851452 |
| spellingShingle | Magdalena Druszczynska Marcin Wlodarczyk Beata Janiszewska-Drobinska Grzegorz Kielnierowski Joanna Zawadzka Magdalena Kowalewicz-Kulbat Marek Fol Piotr Szpakowski Karolina Rudnicka Magdalena Chmiela Wieslawa Rudnicka Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis Clinical and Developmental Immunology |
| title | Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis |
| title_full | Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis |
| title_fullStr | Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis |
| title_full_unstemmed | Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis |
| title_short | Monocyte Signal Transduction Receptors in Active and Latent Tuberculosis |
| title_sort | monocyte signal transduction receptors in active and latent tuberculosis |
| url | http://dx.doi.org/10.1155/2013/851452 |
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