Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation
Background Previous randomized control trials showed mixed results concerning the effect of omega‐3 fatty acids (n‐3 FAs) on atrial fibrillation (AF). The associations of n‐3 FA blood levels with heart rhythm in patients with established AF are unknown. The goal of this study was to assess the assoc...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027646 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850273635896393728 |
|---|---|
| author | Philipp Baumgartner Martin F. Reiner Andrea Wiencierz Michael Coslovsky Nicole R. Bonetti Mark G. Filipovic Stefanie Aeschbacher Michael Kühne Christine S. Zuern Nicolas Rodondi Jolanda Oberle Giorgio Moschovitis Thomas F. Lüscher Giovanni G. Camici Stefan Osswald David Conen Jürg H. Beer |
| author_facet | Philipp Baumgartner Martin F. Reiner Andrea Wiencierz Michael Coslovsky Nicole R. Bonetti Mark G. Filipovic Stefanie Aeschbacher Michael Kühne Christine S. Zuern Nicolas Rodondi Jolanda Oberle Giorgio Moschovitis Thomas F. Lüscher Giovanni G. Camici Stefan Osswald David Conen Jürg H. Beer |
| author_sort | Philipp Baumgartner |
| collection | DOAJ |
| description | Background Previous randomized control trials showed mixed results concerning the effect of omega‐3 fatty acids (n‐3 FAs) on atrial fibrillation (AF). The associations of n‐3 FA blood levels with heart rhythm in patients with established AF are unknown. The goal of this study was to assess the associations of total and individual n‐3 FA blood levels with AF type (paroxysmal versus nonparoxysmal), heart rate (HR), and HR variability in patients with AF. Methods and Results Total n‐3 FAs, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, and alpha‐linolenic acid blood levels were determined in 1969 patients with known AF from the SWISS‐AF (Swiss Atrial Fibrillation cohort). Individual and total n‐3 FAs were correlated with type of AF, HR, and HR variability using standard logistic and linear regression, adjusted for potential confounders. Only a mild association with nonparoxysmal AF was found with total n‐3 FA (odds ratio [OR], 0.97 [95% CI, 0.89–1.05]) and docosahexaenoic acid (OR, 0.93 [95% CI, 0.82–1.06]), whereas other individual n‐3 FAs showed no association with nonparoxysmal AF. Higher total n‐3 FAs (estimate 0.99 [95% CI, 0.98–1.00]) and higher docosahexaenoic acid (0.99 [95% CI, 0.97–1.00]) tended to be associated with slower HR in multivariate analysis. Docosapentaenoic acid was associated with a lower HR variability triangular index (0.94 [95% CI, 0.89–0.99]). Conclusions We found no strong evidence for an association of n‐3 FA blood levels with AF type, but higher total n‐3 FA levels and docosahexaenoic acid might correlate with lower HR, and docosapentaenoic acid with a lower HR variability triangular index. |
| format | Article |
| id | doaj-art-3a47f5c745eb4930ba4ac0829140726d |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-3a47f5c745eb4930ba4ac0829140726d2025-08-20T01:51:25ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-06-01121110.1161/JAHA.122.027646Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial FibrillationPhilipp Baumgartner0Martin F. Reiner1Andrea Wiencierz2Michael Coslovsky3Nicole R. Bonetti4Mark G. Filipovic5Stefanie Aeschbacher6Michael Kühne7Christine S. Zuern8Nicolas Rodondi9Jolanda Oberle10Giorgio Moschovitis11Thomas F. Lüscher12Giovanni G. Camici13Stefan Osswald14David Conen15Jürg H. Beer16Department of Internal Medicine Cantonal Hospital of Baden Baden SwitzerlandDepartment of Internal Medicine Cantonal Hospital of Baden Baden SwitzerlandClinical Trial Unit, University Hospital of Basel Basel SwitzerlandClinical Trial Unit, University Hospital of Basel Basel SwitzerlandDepartment of Internal Medicine Cantonal Hospital of Baden Baden SwitzerlandDepartment of Anaesthesiology and Pain Medicine, Inselspital Bern University Hospital, University of Bern SwitzerlandDepartment of Cardiology University Hospital of Basel Basel SwitzerlandDepartment of Cardiology University Hospital of Basel Basel SwitzerlandDepartment of Cardiology University Hospital of Basel Basel SwitzerlandDepartment of General Internal Medicine Bern University Hospital, University of Bern SwitzerlandDepartment of General Internal Medicine Bern University Hospital, University of Bern SwitzerlandDivision of Cardiology, Ende Ospedaliero Cantonale (EOC) Ospedale Regionale di Lugano Lugano SwitzerlandRoyal Brompton and Harefield Hospitals London UKCenter for Molecular Cardiology University of Zurich Schlieren SwitzerlandDepartment of Cardiology University Hospital of Basel Basel SwitzerlandPopulation Health Research Institute McMaster University Hamilton CanadaDepartment of Internal Medicine Cantonal Hospital of Baden Baden SwitzerlandBackground Previous randomized control trials showed mixed results concerning the effect of omega‐3 fatty acids (n‐3 FAs) on atrial fibrillation (AF). The associations of n‐3 FA blood levels with heart rhythm in patients with established AF are unknown. The goal of this study was to assess the associations of total and individual n‐3 FA blood levels with AF type (paroxysmal versus nonparoxysmal), heart rate (HR), and HR variability in patients with AF. Methods and Results Total n‐3 FAs, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, and alpha‐linolenic acid blood levels were determined in 1969 patients with known AF from the SWISS‐AF (Swiss Atrial Fibrillation cohort). Individual and total n‐3 FAs were correlated with type of AF, HR, and HR variability using standard logistic and linear regression, adjusted for potential confounders. Only a mild association with nonparoxysmal AF was found with total n‐3 FA (odds ratio [OR], 0.97 [95% CI, 0.89–1.05]) and docosahexaenoic acid (OR, 0.93 [95% CI, 0.82–1.06]), whereas other individual n‐3 FAs showed no association with nonparoxysmal AF. Higher total n‐3 FAs (estimate 0.99 [95% CI, 0.98–1.00]) and higher docosahexaenoic acid (0.99 [95% CI, 0.97–1.00]) tended to be associated with slower HR in multivariate analysis. Docosapentaenoic acid was associated with a lower HR variability triangular index (0.94 [95% CI, 0.89–0.99]). Conclusions We found no strong evidence for an association of n‐3 FA blood levels with AF type, but higher total n‐3 FA levels and docosahexaenoic acid might correlate with lower HR, and docosapentaenoic acid with a lower HR variability triangular index.https://www.ahajournals.org/doi/10.1161/JAHA.122.027646atrial fibrillationheart rateheart rate variabilityomega‐3 fatty acidrhythm type |
| spellingShingle | Philipp Baumgartner Martin F. Reiner Andrea Wiencierz Michael Coslovsky Nicole R. Bonetti Mark G. Filipovic Stefanie Aeschbacher Michael Kühne Christine S. Zuern Nicolas Rodondi Jolanda Oberle Giorgio Moschovitis Thomas F. Lüscher Giovanni G. Camici Stefan Osswald David Conen Jürg H. Beer Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atrial fibrillation heart rate heart rate variability omega‐3 fatty acid rhythm type |
| title | Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation |
| title_full | Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation |
| title_fullStr | Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation |
| title_full_unstemmed | Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation |
| title_short | Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation |
| title_sort | omega 3 fatty acids and heart rhythm rate and variability in atrial fibrillation |
| topic | atrial fibrillation heart rate heart rate variability omega‐3 fatty acid rhythm type |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.027646 |
| work_keys_str_mv | AT philippbaumgartner omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT martinfreiner omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT andreawiencierz omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT michaelcoslovsky omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT nicolerbonetti omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT markgfilipovic omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT stefanieaeschbacher omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT michaelkuhne omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT christineszuern omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT nicolasrodondi omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT jolandaoberle omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT giorgiomoschovitis omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT thomasfluscher omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT giovannigcamici omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT stefanosswald omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT davidconen omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation AT jurghbeer omega3fattyacidsandheartrhythmrateandvariabilityinatrialfibrillation |