Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1

Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1

Abstract Programmed cell death–ligand 1 (PD-L1)/PD-1 axis is crucial for maintenance of immune homeostasis and its impairment partially accounts for the pathogenesis of inflammatory diseases. Hence, augmenting PD-L1/PD-1 signals represents a novel strategy to prevent destructive inflammation and ind...

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Main Authors: Hang Zheng, Mianjing Wang, Junjuan Feng, Yuting Zhang, Haiyan Wu, Min Zhang, He Xiao, Chunxia Qiao, Jing Wang, Longlong Luo, Xinying Li, Jiannan Feng, Yuanqiang Zheng, Yi Wang, Dongsheng Sheng, Guojiang Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
PD-L1
pHLIPva
Acidity
T cell
Immunosuppression
Online Access:https://doi.org/10.1038/s41598-025-98135-4
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