Preventive and Adjunctive Therapeutic Roles of Immune Optimization for Cancer Management: A Mini-review
Pathogenesis of cancers encompasses a wide array of immunological processes underscored by immune dysfunction. Immuno-toxic lifestyle habits (poor diet, inadequate sleep, and lack of exercise) are risk factors for cancer development. Immune optimization interventions are useful for cancer prevention...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | International Journal of Medicine and Health Development |
| Subjects: | |
| Online Access: | https://doi.org/10.4103/ijmh.ijmh_43_24 |
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| Summary: | Pathogenesis of cancers encompasses a wide array of immunological processes underscored by immune dysfunction. Immuno-toxic lifestyle habits (poor diet, inadequate sleep, and lack of exercise) are risk factors for cancer development. Immune optimization interventions are useful for cancer prevention and management. T-cell dysfunction disease mediating models describing immunopathogenesis of immune-mediated inflammatory diseases exist. However, they do not highlight inflammatory dysfunctional processes underlying the diseases concerning toxin-mediated epigenetic T-cell dysfunction. Online searches were conducted on databases such as Google Scholar, PubMed, Biomed Central, and SciELO. Articles were reviewed using keywords such as Cancer, Immune optimization/dysfunction, T lymphocyte activation/dysfunction, and inflammatory cytokines. There is a putative T-cell toxin-mediated dysfunction disease model for multiple endocrine neoplasia, which may apply to other cancers. The putative disease model may be validated by multiomic and radiological studies. Validation of the putative disease model should pave the way for a better understanding of the pathogenesis of cancers. |
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| ISSN: | 2635-3695 2667-2863 |