Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases
Oxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut mic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/6/697 |
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| author | Shani Shoham Noam Pintel Dorit Avni |
| author_facet | Shani Shoham Noam Pintel Dorit Avni |
| author_sort | Shani Shoham |
| collection | DOAJ |
| description | Oxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut microbial health present new opportunities for symptom relief and disease management. Microalgae, known for their potent antioxidant, anti-inflammatory, and prebiotic properties, show promise in alleviating oxidative damage and supporting beneficial gut bacteria. This review explores the multifaceted role of oxidative stress in IBD and highlights the therapeutic potential of microalgae-derived compounds. In addition, it examines the synergistic benefits of combining microalgal antioxidants with probiotics to promote gut homeostasis. Advances in delivery systems, including nanotechnology and symbiotic bacteria–microalgae interactions, are also discussed as emerging approaches for targeted treatment. The review concludes by identifying future research priorities focused on clinical translation and microalgae-based bioengineering innovations to enhance the efficacy and accessibility of therapeutics for IBD patients. |
| format | Article |
| id | doaj-art-3a41bf6bbda743f893bdb75d07cfaf3a |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-3a41bf6bbda743f893bdb75d07cfaf3a2025-08-20T03:32:26ZengMDPI AGAntioxidants2076-39212025-06-0114669710.3390/antiox14060697Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel DiseasesShani Shoham0Noam Pintel1Dorit Avni2Bio-Compounds and Immune-Mediated Diseases Group, MIGAL—Galilee Research Institute, 1101600 Kiryat Shemona, IsraelBio-Compounds and Immune-Mediated Diseases Group, MIGAL—Galilee Research Institute, 1101600 Kiryat Shemona, IsraelBio-Compounds and Immune-Mediated Diseases Group, MIGAL—Galilee Research Institute, 1101600 Kiryat Shemona, IsraelOxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut microbial health present new opportunities for symptom relief and disease management. Microalgae, known for their potent antioxidant, anti-inflammatory, and prebiotic properties, show promise in alleviating oxidative damage and supporting beneficial gut bacteria. This review explores the multifaceted role of oxidative stress in IBD and highlights the therapeutic potential of microalgae-derived compounds. In addition, it examines the synergistic benefits of combining microalgal antioxidants with probiotics to promote gut homeostasis. Advances in delivery systems, including nanotechnology and symbiotic bacteria–microalgae interactions, are also discussed as emerging approaches for targeted treatment. The review concludes by identifying future research priorities focused on clinical translation and microalgae-based bioengineering innovations to enhance the efficacy and accessibility of therapeutics for IBD patients.https://www.mdpi.com/2076-3921/14/6/697inflammatory bowel diseasemicroalgaemicrobiomeoxidative stressantioxidantsROS |
| spellingShingle | Shani Shoham Noam Pintel Dorit Avni Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases Antioxidants inflammatory bowel disease microalgae microbiome oxidative stress antioxidants ROS |
| title | Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases |
| title_full | Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases |
| title_fullStr | Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases |
| title_full_unstemmed | Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases |
| title_short | Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases |
| title_sort | oxidative stress gut bacteria and microalgae a holistic approach to manage inflammatory bowel diseases |
| topic | inflammatory bowel disease microalgae microbiome oxidative stress antioxidants ROS |
| url | https://www.mdpi.com/2076-3921/14/6/697 |
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