Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker
Cancer is a disease with abnormally proliferating cells and therefore proliferation rate is an important index for assessing tumour growth. Ki-67 is a commonly used proliferation marker considered to be an unfavourable prognostic marker in some tumors, while Thymidine kinase 1 (TK1) is an interestin...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-06-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317706479 |
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| author | Jianjun Wang Qi Liu Xiaodie Zhou Yan He Qing Guo Qunli Shi Staffan Eriksson Ji Zhou Ellen He Sven Skog |
| author_facet | Jianjun Wang Qi Liu Xiaodie Zhou Yan He Qing Guo Qunli Shi Staffan Eriksson Ji Zhou Ellen He Sven Skog |
| author_sort | Jianjun Wang |
| collection | DOAJ |
| description | Cancer is a disease with abnormally proliferating cells and therefore proliferation rate is an important index for assessing tumour growth. Ki-67 is a commonly used proliferation marker considered to be an unfavourable prognostic marker in some tumors, while Thymidine kinase 1 (TK1) is an interesting proliferation marker because its levels are highly dependent on the growth stage of cells. To define the immunohistochemistry (IHC) expression of the TK1 in patients with ovarian serous adenocarcinoma and establish its potential role as a new biomarker for progressive disease, we analyzed the expression patterns of TK1 and Ki-67 in 109 patients with ovarian serous adenocarcinoma. TK1 and Ki-67 expression both showed a statistically significant correlation to MD Anderson Cancer Center (MDACC) grade, but not to age, tumour size, lymph node metastasis or pathological TNM (pTNM) stages. TK1 expression, MDACC grades, pathological stages and lymph node metastasis correlate to relapse incident rate and overall survival, but Ki-67 does not. Although TK1 expression, MDACC grade, pTNM stage and lymph node metastasis significantly correlate to relapse in the Cox univariate analysis, in the multivariate Cox analysis only TK1 expression and lymph node metastasis were independent prognostic factors. The overall survival also correlated significantly to TK1 expression, MDACC grade, pTNM stage and lymph node metastasis in the Cox univariate analysis. However, only the pTNM stage was found to be an independent prognostic factor for survival in the Cox multivariate analysis. Therefore, though TK1 expression was an independent prognostic factor for relapse, but not for survival, TK1 is a more informative expression than Ki-67 for LI, relapse and overall survival rates. Thus, when TK1 is combined with MDACC grading, pTNM staging and lymph node metastasis, IHC determination of TK1 expression may improve the overall prediction of prognosis in patients with ovarian cancer. |
| format | Article |
| id | doaj-art-3a41275ea3b94839a1e31f2fba54c7c9 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-3a41275ea3b94839a1e31f2fba54c7c92025-08-20T03:33:35ZengSAGE PublishingTumor Biology1423-03802017-06-013910.1177/1010428317706479Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarkerJianjun Wang0Qi Liu1Xiaodie Zhou2Yan He3Qing Guo4Qunli Shi5Staffan Eriksson6Ji Zhou7Ellen He8Sven Skog9Department of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Gynaecology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Anatomy, Physiology and Biochemistry, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, SwedenSino-Swed Molecular Bio-Medicine Research Institute, Shanghai, ChinaSino-Swed Molecular Bio-Medicine Research Institute, Shanghai, ChinaSino-Swed Molecular Bio-Medicine Research Institute, Shanghai, ChinaCancer is a disease with abnormally proliferating cells and therefore proliferation rate is an important index for assessing tumour growth. Ki-67 is a commonly used proliferation marker considered to be an unfavourable prognostic marker in some tumors, while Thymidine kinase 1 (TK1) is an interesting proliferation marker because its levels are highly dependent on the growth stage of cells. To define the immunohistochemistry (IHC) expression of the TK1 in patients with ovarian serous adenocarcinoma and establish its potential role as a new biomarker for progressive disease, we analyzed the expression patterns of TK1 and Ki-67 in 109 patients with ovarian serous adenocarcinoma. TK1 and Ki-67 expression both showed a statistically significant correlation to MD Anderson Cancer Center (MDACC) grade, but not to age, tumour size, lymph node metastasis or pathological TNM (pTNM) stages. TK1 expression, MDACC grades, pathological stages and lymph node metastasis correlate to relapse incident rate and overall survival, but Ki-67 does not. Although TK1 expression, MDACC grade, pTNM stage and lymph node metastasis significantly correlate to relapse in the Cox univariate analysis, in the multivariate Cox analysis only TK1 expression and lymph node metastasis were independent prognostic factors. The overall survival also correlated significantly to TK1 expression, MDACC grade, pTNM stage and lymph node metastasis in the Cox univariate analysis. However, only the pTNM stage was found to be an independent prognostic factor for survival in the Cox multivariate analysis. Therefore, though TK1 expression was an independent prognostic factor for relapse, but not for survival, TK1 is a more informative expression than Ki-67 for LI, relapse and overall survival rates. Thus, when TK1 is combined with MDACC grading, pTNM staging and lymph node metastasis, IHC determination of TK1 expression may improve the overall prediction of prognosis in patients with ovarian cancer.https://doi.org/10.1177/1010428317706479 |
| spellingShingle | Jianjun Wang Qi Liu Xiaodie Zhou Yan He Qing Guo Qunli Shi Staffan Eriksson Ji Zhou Ellen He Sven Skog Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker Tumor Biology |
| title | Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker |
| title_full | Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker |
| title_fullStr | Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker |
| title_full_unstemmed | Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker |
| title_short | Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker |
| title_sort | thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to ki 67 a new prognostic biomarker |
| url | https://doi.org/10.1177/1010428317706479 |
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