Licochalcone A selectively modulates mTORC1‐TFEB to enhance autophagy and demonstrates neuroprotective effects in a mouse model of Parkinson's disease

Licochalcone A selectively modulates mTORC1‐TFEB to enhance autophagy and demonstrates neuroprotective effects in a mouse model of Parkinson's disease

Abstract Activation of transcription factor EB (TFEB), a key regulator of autophagy induction and lysosomal biogenesis, is considered a promising therapeutic strategy for treating the currently incurable Parkinson's disease (PD). However, most TFEB activators also inhibit mTORC1, which regulate...

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Bibliographic Details
Main Authors: Sisi Wang, Ziyang Ding, Zhou Zhu, Xiaoru Zhong, Ashok Iyaswamy, Yaping Niu, Wei Zhang, Jichao Sun, Yulin Feng, Chuanbin Yang, Jigang Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Brain-X
Subjects:
1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)
autophagy
licochalcone A
Parkinson's disease
Rag GTPase
transcription factor EB (TFEB)
Online Access:https://doi.org/10.1002/brx2.70031
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