Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China
Purpose. To investigate the demographic characteristics, etiology, and comorbidities of Cushing’s syndrome (CS) patients at a large medical center in China. Methods. Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 co...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/7159696 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304614575276032 |
|---|---|
| author | Jingya Zhou Meng Zhang Xue Bai Shengnan Cui Cheng Pang Lin Lu Haiyu Pang Xiaopeng Guo Yi Wang Bing Xing |
| author_facet | Jingya Zhou Meng Zhang Xue Bai Shengnan Cui Cheng Pang Lin Lu Haiyu Pang Xiaopeng Guo Yi Wang Bing Xing |
| author_sort | Jingya Zhou |
| collection | DOAJ |
| description | Purpose. To investigate the demographic characteristics, etiology, and comorbidities of Cushing’s syndrome (CS) patients at a large medical center in China. Methods. Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Results. Cushing’s disease (CD) accounted for 63.0% of CS patients, followed by adrenocortical adenoma (ACA) (20.9%), primary bilateral macronodular adrenal hyperplasia (BMAH) (6.2%), ectopic ACTH syndrome (EAS) (5.9%), primary pigmented nodular adrenocortical disease (PPNAD) (1.8%), and adrenocortical carcinoma (ACC) (1.0%). CD, ACA, ACC, and PPNAD presented marked preponderances in women (4.1 : 1, 10.5 : 1, 4.3 : 1, and 2.3 : 1, respectively), while BMAH (59.8%) and EAS (51.0%) showed slightly higher preponderances in men. CD patients were younger than ACA and EAS patients (36.1±12.9 years vs. 39.4±12.7 years and 36.1±12.9 years vs. 41.0±15.8, P<0.001); PPNAD patients were the youngest (24.2±10.8 years, P<0.001), and BMAH patients were the oldest (51.3±9.9 years, P<0.001). Hypertension, diabetes mellitus, osteoporosis without fractures, osteoporotic fractures, dyslipidemia, and fatty liver occurred more frequently in CD patients than in ACA patients (P<0.001 for all). Osteoporotic fractures were observed more frequently in PPAND than in ACA (26.7% vs. 9.0%, P<0.001) and BMAH (26.7% vs. 4.9%, P<0.001) patients. EAS patients had more severe and diverse comorbidities, with higher prevalences of hypokalemia (52.0%), diabetes mellitus (61.2%), and osteoporotic fractures (28.6%). When adjusted for age, male CD patients were associated with hypertension (OR = 2.266, 95% CI: 1.524–3.371, and P<0.001), osteoporotic fractures (OR = 2.274, 95% CI: 1.568–3.298, and P<0.001), fatty liver (OR = 1.435, 95% CI: 1.028–2.003, and P=0.034), and hypokalemia (OR = 1.944, 95% CI: 1.280–2.951, and P=0.002). Conclusions. The proposed method efficiently evaluates CS patients’ epidemiological profiles using hospital DADs with ICD-10 codes and thus may enrich the limited epidemiological data and contribute to clinical practice for CS. |
| format | Article |
| id | doaj-art-3a39c92086e04e3bbca4609dcca440fa |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-3a39c92086e04e3bbca4609dcca440fa2025-08-20T03:55:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/71596967159696Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in ChinaJingya Zhou0Meng Zhang1Xue Bai2Shengnan Cui3Cheng Pang4Lin Lu5Haiyu Pang6Xiaopeng Guo7Yi Wang8Bing Xing9Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaCentral Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaKey Laboratory of Endocrinology of National Health Commission of People’s Republic of China, Beijing 100730, ChinaDepartment of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaKey Laboratory of Endocrinology of National Health Commission of People’s Republic of China, Beijing 100730, ChinaPurpose. To investigate the demographic characteristics, etiology, and comorbidities of Cushing’s syndrome (CS) patients at a large medical center in China. Methods. Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes. Demographic characteristics, etiology, and comorbidity data were analyzed. Results. Cushing’s disease (CD) accounted for 63.0% of CS patients, followed by adrenocortical adenoma (ACA) (20.9%), primary bilateral macronodular adrenal hyperplasia (BMAH) (6.2%), ectopic ACTH syndrome (EAS) (5.9%), primary pigmented nodular adrenocortical disease (PPNAD) (1.8%), and adrenocortical carcinoma (ACC) (1.0%). CD, ACA, ACC, and PPNAD presented marked preponderances in women (4.1 : 1, 10.5 : 1, 4.3 : 1, and 2.3 : 1, respectively), while BMAH (59.8%) and EAS (51.0%) showed slightly higher preponderances in men. CD patients were younger than ACA and EAS patients (36.1±12.9 years vs. 39.4±12.7 years and 36.1±12.9 years vs. 41.0±15.8, P<0.001); PPNAD patients were the youngest (24.2±10.8 years, P<0.001), and BMAH patients were the oldest (51.3±9.9 years, P<0.001). Hypertension, diabetes mellitus, osteoporosis without fractures, osteoporotic fractures, dyslipidemia, and fatty liver occurred more frequently in CD patients than in ACA patients (P<0.001 for all). Osteoporotic fractures were observed more frequently in PPAND than in ACA (26.7% vs. 9.0%, P<0.001) and BMAH (26.7% vs. 4.9%, P<0.001) patients. EAS patients had more severe and diverse comorbidities, with higher prevalences of hypokalemia (52.0%), diabetes mellitus (61.2%), and osteoporotic fractures (28.6%). When adjusted for age, male CD patients were associated with hypertension (OR = 2.266, 95% CI: 1.524–3.371, and P<0.001), osteoporotic fractures (OR = 2.274, 95% CI: 1.568–3.298, and P<0.001), fatty liver (OR = 1.435, 95% CI: 1.028–2.003, and P=0.034), and hypokalemia (OR = 1.944, 95% CI: 1.280–2.951, and P=0.002). Conclusions. The proposed method efficiently evaluates CS patients’ epidemiological profiles using hospital DADs with ICD-10 codes and thus may enrich the limited epidemiological data and contribute to clinical practice for CS.http://dx.doi.org/10.1155/2019/7159696 |
| spellingShingle | Jingya Zhou Meng Zhang Xue Bai Shengnan Cui Cheng Pang Lin Lu Haiyu Pang Xiaopeng Guo Yi Wang Bing Xing Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China International Journal of Endocrinology |
| title | Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China |
| title_full | Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China |
| title_fullStr | Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China |
| title_full_unstemmed | Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China |
| title_short | Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China |
| title_sort | demographic characteristics etiology and comorbidities of patients with cushing s syndrome a 10 year retrospective study at a large general hospital in china |
| url | http://dx.doi.org/10.1155/2019/7159696 |
| work_keys_str_mv | AT jingyazhou demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT mengzhang demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT xuebai demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT shengnancui demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT chengpang demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT linlu demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT haiyupang demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT xiaopengguo demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT yiwang demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina AT bingxing demographiccharacteristicsetiologyandcomorbiditiesofpatientswithcushingssyndromea10yearretrospectivestudyatalargegeneralhospitalinchina |