Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants
Abstract Objective: We compared indices for cerebrovascular health (i.e., physiological responses to tilts by measuring regional cerebral oxygenation [rcSO2], cerebrovascular stability, and cerebral fractional tissue oxygen extraction [FTOE]) in infants with congenital heart disease (CHD) versus h...
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Cambridge University Press
2025-01-01
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| Series: | Journal of Clinical and Translational Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866125101064/type/journal_article |
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| author | Nhu N. Tran Jodie K. Votava-Smith John C. Wood Joanne Yip Andrew Pham Mary-Lynn Brecht Panteha Hayati Rezvan Anthony R. Colombo Philippe Friedlich Ken M. Brady Bradley S. Peterson |
| author_facet | Nhu N. Tran Jodie K. Votava-Smith John C. Wood Joanne Yip Andrew Pham Mary-Lynn Brecht Panteha Hayati Rezvan Anthony R. Colombo Philippe Friedlich Ken M. Brady Bradley S. Peterson |
| author_sort | Nhu N. Tran |
| collection | DOAJ |
| description |
Abstract
Objective:
We compared indices for cerebrovascular health (i.e., physiological responses to tilts by measuring regional cerebral oxygenation [rcSO2], cerebrovascular stability, and cerebral fractional tissue oxygen extraction [FTOE]) in infants with congenital heart disease (CHD) versus healthy controls (HC) at neonatal and 3-month ages.
Study design:
Our cohort study included 101 neonates (52 CHD, 49 HC) and 108 infants at 3-months (45 CHD, 63 HC). We used an innovative and replicable evaluation tool to noninvasively and rapidly measure indices of cerebrovascular health. Changes in near infrared spectroscopy measures of rcSO2 after tilting (from supine to sitting, ∼150 values) assessed cerebrovascular stability. Mixed-effects regression models examined rcSO2 and FTOE differences between groups, and group-by-posture interactions, adjusting for postconceptional age, sex, ethnicity, and preductal systemic oxygenation (SpO2) at both ages.
Results:
Infants with CHD had significantly lower rcSO2 (13% at neonatal and 11% at 3-months, both p < 0.001), increased FTOE (∼0.14 points higher at neonatal and ∼ 0.09 points at 3-months, both p < 0.001), and reduced cerebrovascular stability compared with HC at both ages (both p < 0.001).
Conclusions:
CHD infants had persistently poorer indices of cerebrovascular health (i.e., lower rcSO2, increased FTOE, and reduced cerebrovascular stability) through the 3-month age compared to controls. Sustained cerebral hypoxia, reduced cerebrovascular stability, and increased FTOE may contribute to neurodevelopmental delays (NDDs) and could serve as early biomarkers for identifying infants at higher risk for NDD.
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| format | Article |
| id | doaj-art-3a3073550f9d4246a75fae84e5118964 |
| institution | Kabale University |
| issn | 2059-8661 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj-art-3a3073550f9d4246a75fae84e51189642025-08-20T03:47:13ZengCambridge University PressJournal of Clinical and Translational Science2059-86612025-01-01910.1017/cts.2025.10106Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infantsNhu N. Tran0https://orcid.org/0000-0002-3429-6415Jodie K. Votava-Smith1John C. Wood2Joanne Yip3Andrew Pham4Mary-Lynn Brecht5Panteha Hayati Rezvan6Anthony R. Colombo7Philippe Friedlich8Ken M. Brady9Bradley S. Peterson10Institute for the Developing Mind, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Los Angeles, CA, USADepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USADepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USAKeck School of Medicine, University of Southern California, Los Angeles, CA, USA Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USAKeck School of Medicine, University of Southern California, Los Angeles, CA, USA Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USASchool of Nursing, University of California, Los Angeles, CA, USABiostatistics and Data Management Core, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USADepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USADepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Los Angeles, CA, USALurie Children’s Hospital of Chicago, Anesthesiology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USAInstitute for the Developing Mind, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Abstract Objective: We compared indices for cerebrovascular health (i.e., physiological responses to tilts by measuring regional cerebral oxygenation [rcSO2], cerebrovascular stability, and cerebral fractional tissue oxygen extraction [FTOE]) in infants with congenital heart disease (CHD) versus healthy controls (HC) at neonatal and 3-month ages. Study design: Our cohort study included 101 neonates (52 CHD, 49 HC) and 108 infants at 3-months (45 CHD, 63 HC). We used an innovative and replicable evaluation tool to noninvasively and rapidly measure indices of cerebrovascular health. Changes in near infrared spectroscopy measures of rcSO2 after tilting (from supine to sitting, ∼150 values) assessed cerebrovascular stability. Mixed-effects regression models examined rcSO2 and FTOE differences between groups, and group-by-posture interactions, adjusting for postconceptional age, sex, ethnicity, and preductal systemic oxygenation (SpO2) at both ages. Results: Infants with CHD had significantly lower rcSO2 (13% at neonatal and 11% at 3-months, both p < 0.001), increased FTOE (∼0.14 points higher at neonatal and ∼ 0.09 points at 3-months, both p < 0.001), and reduced cerebrovascular stability compared with HC at both ages (both p < 0.001). Conclusions: CHD infants had persistently poorer indices of cerebrovascular health (i.e., lower rcSO2, increased FTOE, and reduced cerebrovascular stability) through the 3-month age compared to controls. Sustained cerebral hypoxia, reduced cerebrovascular stability, and increased FTOE may contribute to neurodevelopmental delays (NDDs) and could serve as early biomarkers for identifying infants at higher risk for NDD. https://www.cambridge.org/core/product/identifier/S2059866125101064/type/journal_articleCerebrovascular stabilitycerebrovascular oxygenationcerebral fractional tissue oxygen extractioncongenital heart diseaseinfants |
| spellingShingle | Nhu N. Tran Jodie K. Votava-Smith John C. Wood Joanne Yip Andrew Pham Mary-Lynn Brecht Panteha Hayati Rezvan Anthony R. Colombo Philippe Friedlich Ken M. Brady Bradley S. Peterson Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants Journal of Clinical and Translational Science Cerebrovascular stability cerebrovascular oxygenation cerebral fractional tissue oxygen extraction congenital heart disease infants |
| title | Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants |
| title_full | Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants |
| title_fullStr | Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants |
| title_full_unstemmed | Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants |
| title_short | Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants |
| title_sort | neonatal and 3 month cerebrovascular oxygenation stability and extraction in congenital heart disease versus control infants |
| topic | Cerebrovascular stability cerebrovascular oxygenation cerebral fractional tissue oxygen extraction congenital heart disease infants |
| url | https://www.cambridge.org/core/product/identifier/S2059866125101064/type/journal_article |
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