Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model
Physalis peruviana L. (golden berry) fruit is attractive for its many health benefits, associated with the presence of anti-inflammatory and antioxidant compounds. High fruit consumption has been associated with a lower risk of developing chronic non-communicable diseases. This work evaluated the an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000076 |
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| author | Jenny Castro Guillermo Lopez-Lluch Juan Carlos Rodríguez Rocío de la Puerta Lía Barrios Rubén Salas Luis Franco |
| author_facet | Jenny Castro Guillermo Lopez-Lluch Juan Carlos Rodríguez Rocío de la Puerta Lía Barrios Rubén Salas Luis Franco |
| author_sort | Jenny Castro |
| collection | DOAJ |
| description | Physalis peruviana L. (golden berry) fruit is attractive for its many health benefits, associated with the presence of anti-inflammatory and antioxidant compounds. High fruit consumption has been associated with a lower risk of developing chronic non-communicable diseases. This work evaluated the anti-inflammatory potential of ten fruits cultivated in Colombia, determining their capacity to inhibit ⋅NO production in LPS-activated RAW 264.7 macrophages. The most active extracts were evaluated for their effect on the production of IL-1β, IL-6, TNF-α, and PGE2. Golden berry was the most active extract, so its immunomodulatory effect was evaluated in a model of DSS-induced colitis in BALB/c mice. Dietary supplementation with golden berry attenuates the pathological symptoms of colitis. This effect may be associated with the inhibition of neutrophil infiltration and impacts on the production of IL-6, IL-1β, IL-10, TNF-α, and ROS. Our results suggest that consistently consuming golden berries could benefit intestinal inflammation. |
| format | Article |
| id | doaj-art-3a2dce3d866c4ced816127fb4ebc06b5 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3a2dce3d866c4ced816127fb4ebc06b52025-02-09T04:59:54ZengElsevierJournal of Functional Foods1756-46462025-02-01125106665Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis modelJenny Castro0Guillermo Lopez-Lluch1Juan Carlos Rodríguez2Rocío de la Puerta3Lía Barrios4Rubén Salas5Luis Franco6Biological Evaluation of Promising Substances Group, Universidad de Cartagena, Cartagena, Colombia; Faculty of Chemistry and Pharmacy, Universidad del Atlántico, Barranquilla 081007, ColombiaCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Sevilla, SpainDepartamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, SpainDepartment of Pharmacology, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainHistopathology Research Group, Universidad de Cartagena, Cartagena, ColombiaBiological Evaluation of Promising Substances Group, Universidad de Cartagena, Cartagena, ColombiaBiological Evaluation of Promising Substances Group, Universidad de Cartagena, Cartagena, Colombia; Corresponding author at: Biological Evaluation of Promising Substances Group, Facultad de Ciencias Farmacéuticas, Universidad de Cartagena, Zaragocilla Campus, Calle 50 No. 24–120, Cartagena 130014, Colombia.Physalis peruviana L. (golden berry) fruit is attractive for its many health benefits, associated with the presence of anti-inflammatory and antioxidant compounds. High fruit consumption has been associated with a lower risk of developing chronic non-communicable diseases. This work evaluated the anti-inflammatory potential of ten fruits cultivated in Colombia, determining their capacity to inhibit ⋅NO production in LPS-activated RAW 264.7 macrophages. The most active extracts were evaluated for their effect on the production of IL-1β, IL-6, TNF-α, and PGE2. Golden berry was the most active extract, so its immunomodulatory effect was evaluated in a model of DSS-induced colitis in BALB/c mice. Dietary supplementation with golden berry attenuates the pathological symptoms of colitis. This effect may be associated with the inhibition of neutrophil infiltration and impacts on the production of IL-6, IL-1β, IL-10, TNF-α, and ROS. Our results suggest that consistently consuming golden berries could benefit intestinal inflammation.http://www.sciencedirect.com/science/article/pii/S1756464625000076Physalis peruviana LGolden berryDietary supplementsRAW 264.7Inflammatory bowel diseaseDextran sodium sulphate-induced acute colitis |
| spellingShingle | Jenny Castro Guillermo Lopez-Lluch Juan Carlos Rodríguez Rocío de la Puerta Lía Barrios Rubén Salas Luis Franco Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model Journal of Functional Foods Physalis peruviana L Golden berry Dietary supplements RAW 264.7 Inflammatory bowel disease Dextran sodium sulphate-induced acute colitis |
| title | Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model |
| title_full | Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model |
| title_fullStr | Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model |
| title_full_unstemmed | Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model |
| title_short | Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model |
| title_sort | golden berry fruit modulates inflammation in lps stimulated raw 264 7 macrophages and the dss induced acute colitis model |
| topic | Physalis peruviana L Golden berry Dietary supplements RAW 264.7 Inflammatory bowel disease Dextran sodium sulphate-induced acute colitis |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000076 |
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