Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study
Background Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million adults aged 30 to 79 yea...
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Wiley
2016-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.004687 |
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| author | Na Liu Xiong‐Fei Pan Canqing Yu Jun Lv Yu Guo Zheng Bian Ling Yang Yiping Chen Tangchun Wu Zhengming Chen An Pan Liming Li |
| author_facet | Na Liu Xiong‐Fei Pan Canqing Yu Jun Lv Yu Guo Zheng Bian Ling Yang Yiping Chen Tangchun Wu Zhengming Chen An Pan Liming Li |
| author_sort | Na Liu |
| collection | DOAJ |
| description | Background Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004–2008) until December 31, 2013. Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview‐Short Form at baseline. Incident IHD cases were identified through linkage to related medical databases, and defined as having International Statistical Classification of Diseases and Related Health Problems 10th Revision codes of I20 to I25. Cox proportional hazards regression models were used to estimate hazard ratios and 95% CIs for the MD‐IHD association with adjustment for sociodemographic variables and established cardiovascular risk factors. During 3 423 542 person‐years of follow‐up, 24 705 incident IHD cases were documented. Higher IHD incidence was observed in participants with MD compared with those without (8.76 versus 7.21 per 1000 person‐years), and the multivariable‐adjusted hazard ratio was 1.32 (95% CI 1.15–1.53). Geographic location modified the association (P for interaction=0.005), and a positive association was observed in urban residents (hazard ratio 1.72; 95% CI 1.39–2.14) but not rural residents (1.13; 0.93–1.37). Compared with participants without depressive symptoms, the hazard ratio (95% CI) of IHD was 1.13 (1.04–1.23) for those with depressive symptoms only and 1.33 (1.15–1.53) for those with MD. Conclusions Past year major depression was associated with an increased risk of IHD in Chinese adults, independent of other major cardiovascular risk factors. |
| format | Article |
| id | doaj-art-3a1ed5b68a5f4b43802eb33f8fedf10f |
| institution | DOAJ |
| issn | 2047-9980 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-3a1ed5b68a5f4b43802eb33f8fedf10f2025-08-20T02:44:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-12-0151210.1161/JAHA.116.004687Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank StudyNa Liu0Xiong‐Fei Pan1Canqing Yu2Jun Lv3Yu Guo4Zheng Bian5Ling Yang6Yiping Chen7Tangchun Wu8Zhengming Chen9An Pan10Liming Li11Department of Nutrition and Food Hygiene Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing ChinaDepartment of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing ChinaChinese Academy of Medical Sciences Beijing ChinaChinese Academy of Medical Sciences Beijing ChinaClinical Trial Service Unit & Epidemiological Studies Unit (CTSU) Nuffield Department of Population Health University of Oxford United KingdomClinical Trial Service Unit & Epidemiological Studies Unit (CTSU) Nuffield Department of Population Health University of Oxford United KingdomDepartment of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaClinical Trial Service Unit & Epidemiological Studies Unit (CTSU) Nuffield Department of Population Health University of Oxford United KingdomDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing ChinaBackground Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004–2008) until December 31, 2013. Past year MD was measured with the modified Chinese version of Composite International Diagnostic Interview‐Short Form at baseline. Incident IHD cases were identified through linkage to related medical databases, and defined as having International Statistical Classification of Diseases and Related Health Problems 10th Revision codes of I20 to I25. Cox proportional hazards regression models were used to estimate hazard ratios and 95% CIs for the MD‐IHD association with adjustment for sociodemographic variables and established cardiovascular risk factors. During 3 423 542 person‐years of follow‐up, 24 705 incident IHD cases were documented. Higher IHD incidence was observed in participants with MD compared with those without (8.76 versus 7.21 per 1000 person‐years), and the multivariable‐adjusted hazard ratio was 1.32 (95% CI 1.15–1.53). Geographic location modified the association (P for interaction=0.005), and a positive association was observed in urban residents (hazard ratio 1.72; 95% CI 1.39–2.14) but not rural residents (1.13; 0.93–1.37). Compared with participants without depressive symptoms, the hazard ratio (95% CI) of IHD was 1.13 (1.04–1.23) for those with depressive symptoms only and 1.33 (1.15–1.53) for those with MD. Conclusions Past year major depression was associated with an increased risk of IHD in Chinese adults, independent of other major cardiovascular risk factors.https://www.ahajournals.org/doi/10.1161/JAHA.116.004687Chinesedepressionischemic heart diseaseprospective cohort study |
| spellingShingle | Na Liu Xiong‐Fei Pan Canqing Yu Jun Lv Yu Guo Zheng Bian Ling Yang Yiping Chen Tangchun Wu Zhengming Chen An Pan Liming Li Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease Chinese depression ischemic heart disease prospective cohort study |
| title | Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study |
| title_full | Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study |
| title_fullStr | Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study |
| title_full_unstemmed | Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study |
| title_short | Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study |
| title_sort | association of major depression with risk of ischemic heart disease in a mega cohort of chinese adults the china kadoorie biobank study |
| topic | Chinese depression ischemic heart disease prospective cohort study |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.004687 |
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