ROCK1 and LIMK2 interact in spread but not blebbing cancer cells.

ROCK1 and LIMK2 interact in spread but not blebbing cancer cells.

Cancer cells migrating within a 3D microenvironment are able to adopt either a mesenchymal or amoeboid mode of migration. Amoeboid migration is characterised by membrane blebbing that is dependent on the Rho effectors, ROCK1/2. We identify LIMK2 as the preferred substrate for ROCK1 but find that LIM...

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Bibliographic Details
Main Authors: Kerry F Shea, Claire M Wells, Andrew P Garner, Gareth E Jones
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003398&type=printable
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