Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study
Pulmonary hypoplasia is a substantial cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Lung growth is influenced by physical factors such as the intrauterine space, lung liquid volume and pressure, and fetal breathing movements. During lung...
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Elsevier
2017-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957216300626 |
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| author | Chun-Shan Wu Chung-Ming Chen Hsiu-Chu Chou |
| author_facet | Chun-Shan Wu Chung-Ming Chen Hsiu-Chu Chou |
| author_sort | Chun-Shan Wu |
| collection | DOAJ |
| description | Pulmonary hypoplasia is a substantial cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Lung growth is influenced by physical factors such as the intrauterine space, lung liquid volume and pressure, and fetal breathing movements. During lung development, the main physical force experienced by the lungs is stretching induced by breathing movements and the lung fluid in the airspaces. Oligohydramnios reduces the intrathoracic cavity size, thus disrupting fetal lung growth and leading to pulmonary hypoplasia. The exact mechanism by which oligohydramnios alters the respiratory system structure and the effect of oligohydramnios on long-term respiratory outcomes remain unknown. In this review, we summarize the effects of oligohydramnios on lung development, discuss the mechanisms of oligohydramnios-induced pulmonary hypoplasia identified in various animal studies, and describe the long-term respiratory outcomes in childhood of oligohydramnios-exposed fetuses reported by a population-based study. |
| format | Article |
| id | doaj-art-3a1d4ded364647a7a33aee9bc4ade547 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-3a1d4ded364647a7a33aee9bc4ade5472025-08-20T03:06:13ZengElsevierPediatrics and Neonatology1875-95722017-02-015813710.1016/j.pedneo.2016.04.001Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based StudyChun-Shan Wu0Chung-Ming Chen1Hsiu-Chu Chou2Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, TaiwanDepartment of Pediatrics, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanPulmonary hypoplasia is a substantial cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Lung growth is influenced by physical factors such as the intrauterine space, lung liquid volume and pressure, and fetal breathing movements. During lung development, the main physical force experienced by the lungs is stretching induced by breathing movements and the lung fluid in the airspaces. Oligohydramnios reduces the intrathoracic cavity size, thus disrupting fetal lung growth and leading to pulmonary hypoplasia. The exact mechanism by which oligohydramnios alters the respiratory system structure and the effect of oligohydramnios on long-term respiratory outcomes remain unknown. In this review, we summarize the effects of oligohydramnios on lung development, discuss the mechanisms of oligohydramnios-induced pulmonary hypoplasia identified in various animal studies, and describe the long-term respiratory outcomes in childhood of oligohydramnios-exposed fetuses reported by a population-based study.http://www.sciencedirect.com/science/article/pii/S1875957216300626alveolarizationcollagenelastinplatelet-derived growth factortransforming growth factorvascular endothelial growth factor |
| spellingShingle | Chun-Shan Wu Chung-Ming Chen Hsiu-Chu Chou Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study Pediatrics and Neonatology alveolarization collagen elastin platelet-derived growth factor transforming growth factor vascular endothelial growth factor |
| title | Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study |
| title_full | Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study |
| title_fullStr | Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study |
| title_full_unstemmed | Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study |
| title_short | Pulmonary Hypoplasia Induced by Oligohydramnios: Findings from Animal Models and a Population-Based Study |
| title_sort | pulmonary hypoplasia induced by oligohydramnios findings from animal models and a population based study |
| topic | alveolarization collagen elastin platelet-derived growth factor transforming growth factor vascular endothelial growth factor |
| url | http://www.sciencedirect.com/science/article/pii/S1875957216300626 |
| work_keys_str_mv | AT chunshanwu pulmonaryhypoplasiainducedbyoligohydramniosfindingsfromanimalmodelsandapopulationbasedstudy AT chungmingchen pulmonaryhypoplasiainducedbyoligohydramniosfindingsfromanimalmodelsandapopulationbasedstudy AT hsiuchuchou pulmonaryhypoplasiainducedbyoligohydramniosfindingsfromanimalmodelsandapopulationbasedstudy |