Novel pyran-based anti-inflammatory agents: design, synthesis, and mechanistic studies in LPS-stimulated macrophages

Novel pyran-based anti-inflammatory agents: design, synthesis, and mechanistic studies in LPS-stimulated macrophages

Abstract This study investigated the anti-inflammatory effects of pyran derivatives, focusing on compound 19, in LPS-stimulated RAW264.7 macrophages. We screened 19 pyran derivatives for cytotoxicity and nitric oxide (NO) inhibition, and identified compound 19 as the most promising compound owing to...

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Bibliographic Details
Main Authors: Mei Tong He, Sung Jin Kim, Viet Duc Le, Su Ji Min, Heesu Lee, Jae Wook Lee, Myoung-Sook Shin
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:Applied Biological Chemistry
Subjects:
Inflammation
Pyran derivatives
MAPKs
Online Access:https://doi.org/10.1186/s13765-025-01018-5
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