DNA methylation of leptin before and after weight loss intervention program among sample of Egyptian obese females: Epigenetic approach in obesity

DNA methylation of leptin before and after weight loss intervention program among sample of Egyptian obese females: Epigenetic approach in obesity

Background/aim Obesity phenotype results from interactions between epigenotype and genotype. DNA methylation constitutes the most relevant epigenetic mechanism that regulates gene expression in human cells. Leptin (LEP) has a promoter region that presents CpG (CG dinucleotide repeats) islands which...

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Bibliographic Details
Main Authors: Nayera E. Hassan, Sahar A. El-Masry, Waheba A. Zarouk, Nayra S. Mehanna, Rehab M. Mosaad, Maha M Kobesiy, Mohamed S. Kishta, Mohamed Selim, Mahmoud A.S. Afify, Khadija Alian, Aya Khalil, Heba T. Aboud
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Journal of the Arab Society for Medical Research
Subjects:
diet intervention
leptin levels
leptin promoter methylation
obesity
Online Access:https://journals.lww.com/10.4103/jasmr.jasmr_8_24
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