Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel

Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel

Abstract Piezo1 is a mechanosensitive cation channel expressed in intestinal muscularis cells (IMCs), including smooth muscle cells (SMCs), interstitial cells of Cajal, and Pdgfrα+ cells, which form the SIP syncytium, crucial for GI contractility. Here, we investigate the effects of SMC-specific Pie...

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Bibliographic Details
Main Authors: Geoanna M. Bautista, Yingjie Du, Michael J. Matthews, Allison M. Flores, Nicole R. Kushnir, Nicolle K. Sweeney, Nam Phuong N. Nguyen, Elmira Tokhtaeva, R. S. Solorzano-Vargas, Michael Lewis, Matthias Stelzner, Ximin He, James C. Y. Dunn, Martin G. Martin
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07697-6
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