Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons
Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off‐target effects, but struggles with drug degradation. Over...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-11-01
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| Series: | Small Science |
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| Online Access: | https://doi.org/10.1002/smsc.202400280 |
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| author | Minhye Kim Myeongyeon Shin Yaping Zhao Mrinmoy Ghosh Young‐Ok Son |
| author_facet | Minhye Kim Myeongyeon Shin Yaping Zhao Mrinmoy Ghosh Young‐Ok Son |
| author_sort | Minhye Kim |
| collection | DOAJ |
| description | Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off‐target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offer a solution with a small size, high surface‐to‐volume ratios, and customizable properties. These systems address physiological and biological challenges, such as shear stress, protein adsorption, and quick clearance. They allow targeted delivery to specific tissues, improve treatment outcomes, and reduce adverse effects. Nanocarriers exhibit controlled release, decreased degradation, and enhanced efficacy. Their size facilitates cell membrane penetration and intracellular delivery. Surface modifications increase affinity for specific cell types, allowing precise treatment delivery. This study also elucidates the potential integration of artificial intelligence with nanoscience to innovate future nanocarrier systems. |
| format | Article |
| id | doaj-art-3a0ebc9e9829415ebe65fc8083be1f63 |
| institution | OA Journals |
| issn | 2688-4046 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj-art-3a0ebc9e9829415ebe65fc8083be1f632025-08-20T02:14:10ZengWiley-VCHSmall Science2688-40462024-11-01411n/an/a10.1002/smsc.202400280Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic HorizonsMinhye Kim0Myeongyeon Shin1Yaping Zhao2Mrinmoy Ghosh3Young‐Ok Son4Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju‐si Jeju Special Self‐Governing Province 63243 Republic of KoreaDepartment of Animal Biotechnology Faculty of Biotechnology College of Applied Life Sciences Jeju National University Jeju‐si Jeju Special Self‐Governing Province 63243 Republic of KoreaSchool of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University Shanghai 200240 P. R. ChinaDepartment of Animal Biotechnology Faculty of Biotechnology College of Applied Life Sciences Jeju National University Jeju‐si Jeju Special Self‐Governing Province 63243 Republic of KoreaInterdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju‐si Jeju Special Self‐Governing Province 63243 Republic of KoreaAdvancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off‐target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offer a solution with a small size, high surface‐to‐volume ratios, and customizable properties. These systems address physiological and biological challenges, such as shear stress, protein adsorption, and quick clearance. They allow targeted delivery to specific tissues, improve treatment outcomes, and reduce adverse effects. Nanocarriers exhibit controlled release, decreased degradation, and enhanced efficacy. Their size facilitates cell membrane penetration and intracellular delivery. Surface modifications increase affinity for specific cell types, allowing precise treatment delivery. This study also elucidates the potential integration of artificial intelligence with nanoscience to innovate future nanocarrier systems.https://doi.org/10.1002/smsc.202400280hybrid nanocarriersliposomesnanocarriersnanoemulsionspolymeric |
| spellingShingle | Minhye Kim Myeongyeon Shin Yaping Zhao Mrinmoy Ghosh Young‐Ok Son Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons Small Science hybrid nanocarriers liposomes nanocarriers nanoemulsions polymeric |
| title | Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons |
| title_full | Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons |
| title_fullStr | Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons |
| title_full_unstemmed | Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons |
| title_short | Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons |
| title_sort | transformative impact of nanocarrier mediated drug delivery overcoming biological barriers and expanding therapeutic horizons |
| topic | hybrid nanocarriers liposomes nanocarriers nanoemulsions polymeric |
| url | https://doi.org/10.1002/smsc.202400280 |
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