Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia
Streptococcus pneumoniae is an important pathogen causing public health problems worldwide. Existing pneumococcal vaccines provide protection against only a few of the more than 100 pneumococcal serotypes, highlighting the urgent need for new preventive strategies. Pneumococcal protein vaccines have...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563661/full |
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| author | Fangyu Ren Fangyu Ren Luyun Huang Luyun Huang Shilu Luo Shilu Luo Changjin Liu Changjin Liu Xianlian Chen Xianlian Chen Xin Yao Xin Yao Qiqi Linghu Qiqi Linghu Huaqin Hu Huaqin Hu Xiaoyu Huang Xiaoyu Huang Yuanqin Hu Yuanqin Hu Jian Huang Jian Huang Xun Min Xun Min |
| author_facet | Fangyu Ren Fangyu Ren Luyun Huang Luyun Huang Shilu Luo Shilu Luo Changjin Liu Changjin Liu Xianlian Chen Xianlian Chen Xin Yao Xin Yao Qiqi Linghu Qiqi Linghu Huaqin Hu Huaqin Hu Xiaoyu Huang Xiaoyu Huang Yuanqin Hu Yuanqin Hu Jian Huang Jian Huang Xun Min Xun Min |
| author_sort | Fangyu Ren |
| collection | DOAJ |
| description | Streptococcus pneumoniae is an important pathogen causing public health problems worldwide. Existing pneumococcal vaccines provide protection against only a few of the more than 100 pneumococcal serotypes, highlighting the urgent need for new preventive strategies. Pneumococcal protein vaccines have attracted considerable attention owing to their favorable immunogenicity and antigen conservation, and have demonstrated protective potential against non-serotype-dependent infections. Mice immunized with a trivalent vaccine targeting protein PepN, PepO, and SPD_1609 elicited a robust humoral immune response, as well as Th1, Th2, and Th17 cellular immune responses. The antiserum derived from the trivalent vaccine significantly inhibited Streptococcus pneumoniae adhesion to A549 cells, reduced pneumococcal colonization in the nasopharynx, and improved lung tissue damage and inflammatory responses compared to the monovalent or bivalent vaccine group. In terms of in vivo protection, the trivalent vaccine significantly increased the survival rate of infected mice. The findings suggest that the trivalent vaccine targeting PepN, PepO, and SPD_1609 is a promising multivalent vaccine candidate against Streptococcus pneumoniae. |
| format | Article |
| id | doaj-art-3a0e28c845f344adb896ad618212ebfa |
| institution | OA Journals |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-3a0e28c845f344adb896ad618212ebfa2025-08-20T02:35:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.15636611563661Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumoniaFangyu Ren0Fangyu Ren1Luyun Huang2Luyun Huang3Shilu Luo4Shilu Luo5Changjin Liu6Changjin Liu7Xianlian Chen8Xianlian Chen9Xin Yao10Xin Yao11Qiqi Linghu12Qiqi Linghu13Huaqin Hu14Huaqin Hu15Xiaoyu Huang16Xiaoyu Huang17Yuanqin Hu18Yuanqin Hu19Jian Huang20Jian Huang21Xun Min22Xun Min23Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaSchool of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, ChinaStreptococcus pneumoniae is an important pathogen causing public health problems worldwide. Existing pneumococcal vaccines provide protection against only a few of the more than 100 pneumococcal serotypes, highlighting the urgent need for new preventive strategies. Pneumococcal protein vaccines have attracted considerable attention owing to their favorable immunogenicity and antigen conservation, and have demonstrated protective potential against non-serotype-dependent infections. Mice immunized with a trivalent vaccine targeting protein PepN, PepO, and SPD_1609 elicited a robust humoral immune response, as well as Th1, Th2, and Th17 cellular immune responses. The antiserum derived from the trivalent vaccine significantly inhibited Streptococcus pneumoniae adhesion to A549 cells, reduced pneumococcal colonization in the nasopharynx, and improved lung tissue damage and inflammatory responses compared to the monovalent or bivalent vaccine group. In terms of in vivo protection, the trivalent vaccine significantly increased the survival rate of infected mice. The findings suggest that the trivalent vaccine targeting PepN, PepO, and SPD_1609 is a promising multivalent vaccine candidate against Streptococcus pneumoniae.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563661/fullStreptococcus pneumoniaetrivalent vaccinehumoral immunitycellular immunityprotective efficacy |
| spellingShingle | Fangyu Ren Fangyu Ren Luyun Huang Luyun Huang Shilu Luo Shilu Luo Changjin Liu Changjin Liu Xianlian Chen Xianlian Chen Xin Yao Xin Yao Qiqi Linghu Qiqi Linghu Huaqin Hu Huaqin Hu Xiaoyu Huang Xiaoyu Huang Yuanqin Hu Yuanqin Hu Jian Huang Jian Huang Xun Min Xun Min Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia Frontiers in Cellular and Infection Microbiology Streptococcus pneumoniae trivalent vaccine humoral immunity cellular immunity protective efficacy |
| title | Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia |
| title_full | Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia |
| title_fullStr | Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia |
| title_full_unstemmed | Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia |
| title_short | Intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia |
| title_sort | intranasal trivalent candidate vaccine elicits broad humoral and cellular immunity against pneumococcal pneumonia |
| topic | Streptococcus pneumoniae trivalent vaccine humoral immunity cellular immunity protective efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563661/full |
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