Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model
Vitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. Applying β-lactoglobulin with oleic acid (β-Lg-AO) as an encapsulating agent is anticipated to protect and enhance the transport of vitamin D3 to the gastrointestinal system. This...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1514179/full |
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| author | Gemala Anjani Reza Achmad Maulana Sylvia Rahmi Putri Faizah Fulyani Ahmad Syauqy Diana Nur Afifah Fitriyono Ayustaningwarno Refani Alycia Kusuma Zulfatul Masruroh |
| author_facet | Gemala Anjani Reza Achmad Maulana Sylvia Rahmi Putri Faizah Fulyani Ahmad Syauqy Diana Nur Afifah Fitriyono Ayustaningwarno Refani Alycia Kusuma Zulfatul Masruroh |
| author_sort | Gemala Anjani |
| collection | DOAJ |
| description | Vitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. Applying β-lactoglobulin with oleic acid (β-Lg-AO) as an encapsulating agent is anticipated to protect and enhance the transport of vitamin D3 to the gastrointestinal system. This study aimed to evaluate effect of liprotide-encapsulated vitamin D3 in a vitamin D-deficient rat on blood glucose, Vitamin D and calcium status. This is pre-post intervention. 24 mice were divided into 4 groups: (K-) normal rats; (K+) rat model of vitamin D and calcium deficiency; (P1) rat model of vitamin D and calcium deficiency with vitamin D3 intervention; (P2) rat model of vitamin D and calcium deficiency with liprotide-encapsulated vitamin D3 intervention. The administered dose of vitamin D3 was 180 IU (2 mL solution). Liprotide-encapsulated vitamin D3 intervention in vitamin D and calcium deficiency rats can significantly increase vitamin D (25 (OH)D) and calcium levels (p < 0.05). The increase in vitamin D (25 (OH)D) level was 53.69 ng/mL, and the increased calcium level was 4.38 mg/dL. Blood glucose levels of vitamin D-calcium deficiency rats decreased significantly (p < 0.05) by 39.87 mg/dL. Vitamin D3 encapsulated liprotide improves vitamin D and calcium in the blood more effectively than vitamin D3 without encapsulation in deficient rats. |
| format | Article |
| id | doaj-art-3a0af551ca3a4d109467428ab996e27a |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-3a0af551ca3a4d109467428ab996e27a2025-01-28T05:10:30ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15141791514179Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat modelGemala Anjani0Reza Achmad Maulana1Sylvia Rahmi Putri2Faizah Fulyani3Ahmad Syauqy4Diana Nur Afifah5Fitriyono Ayustaningwarno6Refani Alycia Kusuma7Zulfatul Masruroh8Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Nutrition Science, Faculty of Public Health, Ahmad Dahlan University, Yogyakarta, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaVitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. Applying β-lactoglobulin with oleic acid (β-Lg-AO) as an encapsulating agent is anticipated to protect and enhance the transport of vitamin D3 to the gastrointestinal system. This study aimed to evaluate effect of liprotide-encapsulated vitamin D3 in a vitamin D-deficient rat on blood glucose, Vitamin D and calcium status. This is pre-post intervention. 24 mice were divided into 4 groups: (K-) normal rats; (K+) rat model of vitamin D and calcium deficiency; (P1) rat model of vitamin D and calcium deficiency with vitamin D3 intervention; (P2) rat model of vitamin D and calcium deficiency with liprotide-encapsulated vitamin D3 intervention. The administered dose of vitamin D3 was 180 IU (2 mL solution). Liprotide-encapsulated vitamin D3 intervention in vitamin D and calcium deficiency rats can significantly increase vitamin D (25 (OH)D) and calcium levels (p < 0.05). The increase in vitamin D (25 (OH)D) level was 53.69 ng/mL, and the increased calcium level was 4.38 mg/dL. Blood glucose levels of vitamin D-calcium deficiency rats decreased significantly (p < 0.05) by 39.87 mg/dL. Vitamin D3 encapsulated liprotide improves vitamin D and calcium in the blood more effectively than vitamin D3 without encapsulation in deficient rats.https://www.frontiersin.org/articles/10.3389/fnut.2025.1514179/fullencapsulationblood glucosecalciumliprotidevitamin D3 |
| spellingShingle | Gemala Anjani Reza Achmad Maulana Sylvia Rahmi Putri Faizah Fulyani Ahmad Syauqy Diana Nur Afifah Fitriyono Ayustaningwarno Refani Alycia Kusuma Zulfatul Masruroh Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model Frontiers in Nutrition encapsulation blood glucose calcium liprotide vitamin D3 |
| title | Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model |
| title_full | Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model |
| title_fullStr | Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model |
| title_full_unstemmed | Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model |
| title_short | Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model |
| title_sort | ameliorative effect of liprotide encapsulated vitamin d3 on blood glucose calcium homeostasis and vitamin d level in a vitamin d and calcium deficient rat model |
| topic | encapsulation blood glucose calcium liprotide vitamin D3 |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1514179/full |
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