Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes
Abstract The increasing prevalence of antimicrobial resistance underscores the urgent need for alternative treatments. Antimicrobial peptides (AMPs) are considered viable substitutes for conventional antibiotics due to their broad-spectrum activity and unique mechanisms of action. AMPs are an integr...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | AMB Express |
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| Online Access: | https://doi.org/10.1186/s13568-025-01908-3 |
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| author | Jonggwan Park Seulbi Lee Da Dam Kang Jun Hee Oh Hyeongsun Kim Yoonkyung Park |
| author_facet | Jonggwan Park Seulbi Lee Da Dam Kang Jun Hee Oh Hyeongsun Kim Yoonkyung Park |
| author_sort | Jonggwan Park |
| collection | DOAJ |
| description | Abstract The increasing prevalence of antimicrobial resistance underscores the urgent need for alternative treatments. Antimicrobial peptides (AMPs) are considered viable substitutes for conventional antibiotics due to their broad-spectrum activity and unique mechanisms of action. AMPs are an integral component of the innate immune system in invertebrates. Mastoparan-S, a 14-amino acid AMP originally identified in the praying mantis Sphodromantis viridis reportedly exhibits antimicrobial activity against gram-positive and gram-negative bacteria, as well as fungi. In this study, the antibacterial activity and mechanism of action of chemically-synthesized mastoparan-S are evaluated against Staphylococcus aureus and Pseudomonas aeruginosa. Mastoparan-S exhibits potent antibacterial activity against S. aureus and P. aeruginosa, without inducing cytotoxicity or hemolytic activity in RAW264.7 or HaCaT cells. Mastoparan-S effectively inhibits biofilm formation by S. aureus and P. aeruginosa. Mechanistically, mastopran-S kills bacteria by disrupting the bacterial membrane. Collectively, these findings suggest that mastoparan-S is a potential therapeutic agent for treating S. aureus and P. aeruginosa infections. |
| format | Article |
| id | doaj-art-3a06b754e9cd4eca83b3d8ffaebcf040 |
| institution | Kabale University |
| issn | 2191-0855 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj-art-3a06b754e9cd4eca83b3d8ffaebcf0402025-08-20T03:45:32ZengSpringerOpenAMB Express2191-08552025-07-0115111310.1186/s13568-025-01908-3Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranesJonggwan Park0Seulbi Lee1Da Dam Kang2Jun Hee Oh3Hyeongsun Kim4Yoonkyung Park5Department of Bioinformatics, Kongju National UniversityDepartment of Biomedical Science, Chosun UniversityDepartment of Biomedical Science, Chosun UniversityDepartment of Biomedical Science, Chosun UniversityDepartment of Biomedical Science, Chosun UniversityDepartment of Biomedical Science, Chosun UniversityAbstract The increasing prevalence of antimicrobial resistance underscores the urgent need for alternative treatments. Antimicrobial peptides (AMPs) are considered viable substitutes for conventional antibiotics due to their broad-spectrum activity and unique mechanisms of action. AMPs are an integral component of the innate immune system in invertebrates. Mastoparan-S, a 14-amino acid AMP originally identified in the praying mantis Sphodromantis viridis reportedly exhibits antimicrobial activity against gram-positive and gram-negative bacteria, as well as fungi. In this study, the antibacterial activity and mechanism of action of chemically-synthesized mastoparan-S are evaluated against Staphylococcus aureus and Pseudomonas aeruginosa. Mastoparan-S exhibits potent antibacterial activity against S. aureus and P. aeruginosa, without inducing cytotoxicity or hemolytic activity in RAW264.7 or HaCaT cells. Mastoparan-S effectively inhibits biofilm formation by S. aureus and P. aeruginosa. Mechanistically, mastopran-S kills bacteria by disrupting the bacterial membrane. Collectively, these findings suggest that mastoparan-S is a potential therapeutic agent for treating S. aureus and P. aeruginosa infections.https://doi.org/10.1186/s13568-025-01908-3Antimicrobial peptideMastoparan-SStaphylococcus aureusPseudomonas aeruginosa |
| spellingShingle | Jonggwan Park Seulbi Lee Da Dam Kang Jun Hee Oh Hyeongsun Kim Yoonkyung Park Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes AMB Express Antimicrobial peptide Mastoparan-S Staphylococcus aureus Pseudomonas aeruginosa |
| title | Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes |
| title_full | Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes |
| title_fullStr | Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes |
| title_full_unstemmed | Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes |
| title_short | Mastoparan-S from Sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes |
| title_sort | mastoparan s from sphodromantis viridis exhibits antimicrobial activity by disrupting bacterial membranes |
| topic | Antimicrobial peptide Mastoparan-S Staphylococcus aureus Pseudomonas aeruginosa |
| url | https://doi.org/10.1186/s13568-025-01908-3 |
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