Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile
Obesity is considered a significant global health issue. The gut microbiota plays a crucial role in preventing obesity. Sargassum fusiforme and its fucoidan extract have lipid-lowering effects, but their mechanisms are not yet fully understood. This study investigates the mechanisms by exploring cha...
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000283 |
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| author | Xiaoyu Ling Zhengyang Li Ning Su Lingqing Kong Shiwei Han Dafeng Song |
| author_facet | Xiaoyu Ling Zhengyang Li Ning Su Lingqing Kong Shiwei Han Dafeng Song |
| author_sort | Xiaoyu Ling |
| collection | DOAJ |
| description | Obesity is considered a significant global health issue. The gut microbiota plays a crucial role in preventing obesity. Sargassum fusiforme and its fucoidan extract have lipid-lowering effects, but their mechanisms are not yet fully understood. This study investigates the mechanisms by exploring changes in gut microbiota composition, gene expression, and metabolites in mice fed a high-fat diet after intervention with Sargassum fusiforme (SF) and Sargassum fusiforme fucoidan (SFF) through integration of 16S rRNA sequencing, transcriptomics, and non-targeted metabolomics. Our results demonstrate that Sargassum fusiforme can ameliorate high-fat diet-induced obesity by decreasing the abundance of specific Firmicutes phylum bacteria, reducing the levels of glycochenodeoxycholic acid, glycoursodeoxycholic acid, glycohyodeoxycholic acid, and glycodeoxycholic acid, and regulating the expression of the Elovl3, Gm3734, Per2, and Tnnc1 genes. This offers a new perspective for hypercholesterolemia treatment strategies. |
| format | Article |
| id | doaj-art-3a05bc5118b74990834ce7ad83d0f1c3 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3a05bc5118b74990834ce7ad83d0f1c32025-02-09T04:59:57ZengElsevierJournal of Functional Foods1756-46462025-02-01125106686Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profileXiaoyu Ling0Zhengyang Li1Ning Su2Lingqing Kong3Shiwei Han4Dafeng Song5Key Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018 Zhejiang, ChinaKey Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018 Zhejiang, ChinaKey Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018 Zhejiang, ChinaKey Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018 Zhejiang, ChinaKey Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018 Zhejiang, ChinaCorresponding author at: Key Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, No. 18, Xuezheng Str, Hangzhou 310018 Zhejiang, China.; Key Laboratory for Food Microbial Technology of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018 Zhejiang, ChinaObesity is considered a significant global health issue. The gut microbiota plays a crucial role in preventing obesity. Sargassum fusiforme and its fucoidan extract have lipid-lowering effects, but their mechanisms are not yet fully understood. This study investigates the mechanisms by exploring changes in gut microbiota composition, gene expression, and metabolites in mice fed a high-fat diet after intervention with Sargassum fusiforme (SF) and Sargassum fusiforme fucoidan (SFF) through integration of 16S rRNA sequencing, transcriptomics, and non-targeted metabolomics. Our results demonstrate that Sargassum fusiforme can ameliorate high-fat diet-induced obesity by decreasing the abundance of specific Firmicutes phylum bacteria, reducing the levels of glycochenodeoxycholic acid, glycoursodeoxycholic acid, glycohyodeoxycholic acid, and glycodeoxycholic acid, and regulating the expression of the Elovl3, Gm3734, Per2, and Tnnc1 genes. This offers a new perspective for hypercholesterolemia treatment strategies.http://www.sciencedirect.com/science/article/pii/S1756464625000283Gut microbiotaLipid loweringLipid metabolismSargassum fusiforme |
| spellingShingle | Xiaoyu Ling Zhengyang Li Ning Su Lingqing Kong Shiwei Han Dafeng Song Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile Journal of Functional Foods Gut microbiota Lipid lowering Lipid metabolism Sargassum fusiforme |
| title | Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile |
| title_full | Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile |
| title_fullStr | Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile |
| title_full_unstemmed | Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile |
| title_short | Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile |
| title_sort | sargassum fusiforme and its fucoidan alleviates high fat diet induced obesity associated with the improvement of the gut microbiota profile |
| topic | Gut microbiota Lipid lowering Lipid metabolism Sargassum fusiforme |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000283 |
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