HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES
Objective: To determine the prognostic value of high-sensitivity C-reactive protein (hsCRP) levels in the first trimester for the risk of gestational diabetes mellitus (GDM) in obese pregnant women. Methods: A prospective observational descriptive cohort study included 105 obese women with a body...
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| Format: | Article |
| Language: | English |
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Avicenna Tajik State Medical University
2024-12-01
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| Series: | Паёми Сино |
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| Online Access: | https://doi.org/10.25005/2074-0581-2024-26-4-548-555 |
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| author | Belomestnov Sergey Razumovich Сhumarnaya Tatyana Vladislavovna Sevostyanova Olga Yurievna Ksenofontov Aleksey Mikhaylovich Isakova Tatyana Mikhaylovna Prazdnichkova Ekaterina Dmitrievna |
| author_facet | Belomestnov Sergey Razumovich Сhumarnaya Tatyana Vladislavovna Sevostyanova Olga Yurievna Ksenofontov Aleksey Mikhaylovich Isakova Tatyana Mikhaylovna Prazdnichkova Ekaterina Dmitrievna |
| author_sort | Belomestnov Sergey Razumovich |
| collection | DOAJ |
| description | Objective: To determine the prognostic value of high-sensitivity C-reactive protein (hsCRP) levels in the first trimester for the risk of gestational
diabetes mellitus (GDM) in obese pregnant women.
Methods: A prospective observational descriptive cohort study included 105 obese women with a body mass index (BMI) ranging from 25.0 to
29.99 kg/m² in the first trimester. The main group consisted of 31 pregnant patients with GDM. The control group included 74 pregnant women
without carbohydrate metabolism disorders. BMI and hsCRP concentration in venous blood serum were determined for each woman. All laboratory
measurements were performed simultaneously in the same laboratory by the same specialist. The median, 1st, and 3rd quartiles were used to describe
the central tendency. The diagnostic value of the parameters (GDM prognosis) was assessed using the area (AUC) under the characteristic receiveroperating curve (ROC). Differences were considered statistically significant if p<0.05.
Results: A statistically significant increase in the hsCRP concentration was found: 2.5 [0.4; 5.35] mg/l in the main group compared to the 0.4 [0.4; 0.4]
mg/l in the control group (p<0.001). The value of hsCRP for GDM prognosis was confirmed: AUC=0.77 (p<0.001), and the cut-off threshold was 0.5 g/
ml (sensitivity=68%, specificity=85%).Conclusion: The study's findings suggest that an hsCRP concentration above 0.5 mg/l could be a valuable screening tool for obese pregnant women with
normal glycemic levels in the first trimester. This marker could serve as an additional prognostic criterion for GDM, equipping healthcare professionals
with a powerful tool for early risk identification. |
| format | Article |
| id | doaj-art-3a04e393f8544d438fdcaec1b898cb39 |
| institution | Kabale University |
| issn | 2074-0581 2959-6327 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Avicenna Tajik State Medical University |
| record_format | Article |
| series | Паёми Сино |
| spelling | doaj-art-3a04e393f8544d438fdcaec1b898cb392024-12-16T10:01:50ZengAvicenna Tajik State Medical UniversityПаёми Сино2074-05812959-63272024-12-0126454855510.25005/2074-0581-2024-26-4-548-555HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETESBelomestnov Sergey Razumovich0https://orcid.org/0000-0002-4031-4907Сhumarnaya Tatyana Vladislavovna1https://orcid.org/0000-0002-7965-2364Sevostyanova Olga Yurievna2https://orcid.org/0000-0002-0828-0479Ksenofontov Aleksey Mikhaylovich3https://orcid.org/0009-0009-3432-9334Isakova Tatyana Mikhaylovna4https://orcid.org/0000-0003-0050-9301Prazdnichkova Ekaterina Dmitrievna5https://orcid.org/0009-0003-8907-3619Candidate of Medical Sciences, Associate Professor at the Department of Obstetrics and Gynecology, Ural State Medical University; Obstetrician-Gynecologist, Ekaterinburg Clinical Perinatal CenterCandidate of Biological Sciences, Senior Researcher, Laboratory for Mathematical Physiology, Institute of Immunology and Physiology, Ural Branch of the Russian Academy of SciencesDoctor of Medical Sciences, Professor at the Department of Obstetrics and Gynecology, Ural State Medical UniversityObstetrician-Gynecologist, Ekaterinburg Clinical Perinatal CenterCandidate of Medical Sciences, Associate Professor at the Department of Oncology and Radiation Diagnostics, Ural State Medical University Student, Ural State Medical UniversityObjective: To determine the prognostic value of high-sensitivity C-reactive protein (hsCRP) levels in the first trimester for the risk of gestational diabetes mellitus (GDM) in obese pregnant women. Methods: A prospective observational descriptive cohort study included 105 obese women with a body mass index (BMI) ranging from 25.0 to 29.99 kg/m² in the first trimester. The main group consisted of 31 pregnant patients with GDM. The control group included 74 pregnant women without carbohydrate metabolism disorders. BMI and hsCRP concentration in venous blood serum were determined for each woman. All laboratory measurements were performed simultaneously in the same laboratory by the same specialist. The median, 1st, and 3rd quartiles were used to describe the central tendency. The diagnostic value of the parameters (GDM prognosis) was assessed using the area (AUC) under the characteristic receiveroperating curve (ROC). Differences were considered statistically significant if p<0.05. Results: A statistically significant increase in the hsCRP concentration was found: 2.5 [0.4; 5.35] mg/l in the main group compared to the 0.4 [0.4; 0.4] mg/l in the control group (p<0.001). The value of hsCRP for GDM prognosis was confirmed: AUC=0.77 (p<0.001), and the cut-off threshold was 0.5 g/ ml (sensitivity=68%, specificity=85%).Conclusion: The study's findings suggest that an hsCRP concentration above 0.5 mg/l could be a valuable screening tool for obese pregnant women with normal glycemic levels in the first trimester. This marker could serve as an additional prognostic criterion for GDM, equipping healthcare professionals with a powerful tool for early risk identification.https://doi.org/10.25005/2074-0581-2024-26-4-548-555gestational diabetes mellitusobesityc-reactive proteinmetabolic maladaptationpregnancy complications |
| spellingShingle | Belomestnov Sergey Razumovich Сhumarnaya Tatyana Vladislavovna Sevostyanova Olga Yurievna Ksenofontov Aleksey Mikhaylovich Isakova Tatyana Mikhaylovna Prazdnichkova Ekaterina Dmitrievna HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES Паёми Сино gestational diabetes mellitus obesity c-reactive protein metabolic maladaptation pregnancy complications |
| title | HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES |
| title_full | HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES |
| title_fullStr | HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES |
| title_full_unstemmed | HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES |
| title_short | HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES |
| title_sort | high sensitivity c reactive protein in the first trimester of pregnancy in obese patients with gestational diabetes |
| topic | gestational diabetes mellitus obesity c-reactive protein metabolic maladaptation pregnancy complications |
| url | https://doi.org/10.25005/2074-0581-2024-26-4-548-555 |
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