Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine
Artificial gastrointestinal tract models have become essential tools in veterinary medicine, providing alternatives to in vivo studies, which are labor-intensive, costly, and under certain circumstances even ethically challenging. These in vitro models facilitate the study of digestion, enable disea...
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MDPI AG
2025-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/15/9/1222 |
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| author | Sergei Konstantinovich Shebeko Heorhii Yurievich Drobot Andrey Georgievich Koshchaev Svetoslav Dimitrov Todorov Alexey Mikhailovich Ermakov |
| author_facet | Sergei Konstantinovich Shebeko Heorhii Yurievich Drobot Andrey Georgievich Koshchaev Svetoslav Dimitrov Todorov Alexey Mikhailovich Ermakov |
| author_sort | Sergei Konstantinovich Shebeko |
| collection | DOAJ |
| description | Artificial gastrointestinal tract models have become essential tools in veterinary medicine, providing alternatives to in vivo studies, which are labor-intensive, costly, and under certain circumstances even ethically challenging. These in vitro models facilitate the study of digestion, enable disease and host–pathogen interaction modeling, and allow for the investigation of nutrient absorption, microbiota, and pharmacokinetics. Considering the One Health concept, the application of gastrointestinal tract systems in investigations for animals can clearly reflect human health, and thus, it is pointing to the relevance of the adaptation of already existing models and the development of new models to meet the needs of veterinary and animal farming practices. This review explores and compares the various types of gastrointestinal tract models, including static and dynamic systems, and their applications across different animal species. Specific technical and methodological considerations are discussed for core animal-developed and -tested artificial systems and their integration with common ‘omics’ techniques. Dynamic models, such as RUSITEC and PolyFermS, more accurately simulate in vivo processes, including peristalsis, enzymatic activity, and microbial fermentation. The studies employing tools for ‘omics’ approaches have been conducted with more understanding analysis and comprehensive discussion and results. |
| format | Article |
| id | doaj-art-3a03f9facda84c6d818f723d4455e6ae |
| institution | OA Journals |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-3a03f9facda84c6d818f723d4455e6ae2025-08-20T01:49:20ZengMDPI AGAnimals2076-26152025-04-01159122210.3390/ani15091222Application of Artificial Gastrointestinal Tract Models in Veterinary MedicineSergei Konstantinovich Shebeko0Heorhii Yurievich Drobot1Andrey Georgievich Koshchaev2Svetoslav Dimitrov Todorov3Alexey Mikhailovich Ermakov4Faculty of Bioengineering and Veterinary Medicine, Don State Technical University, 1, Gagarina sq., Rostov-on-Don 344000, RussiaFaculty of Bioengineering and Veterinary Medicine, Don State Technical University, 1, Gagarina sq., Rostov-on-Don 344000, RussiaDepartment of Biotechnology, Biochemistry and Biophysics, Kuban State Agrarian University, 13, Kalinina Street, Krasnodar 350044, RussiaProBacLab, Laboratório de Microbiologia de Alimentos, Departamento de Alimentos e Nutrição Experimental, Food Research Center, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo 05508-000, BrazilFaculty of Bioengineering and Veterinary Medicine, Don State Technical University, 1, Gagarina sq., Rostov-on-Don 344000, RussiaArtificial gastrointestinal tract models have become essential tools in veterinary medicine, providing alternatives to in vivo studies, which are labor-intensive, costly, and under certain circumstances even ethically challenging. These in vitro models facilitate the study of digestion, enable disease and host–pathogen interaction modeling, and allow for the investigation of nutrient absorption, microbiota, and pharmacokinetics. Considering the One Health concept, the application of gastrointestinal tract systems in investigations for animals can clearly reflect human health, and thus, it is pointing to the relevance of the adaptation of already existing models and the development of new models to meet the needs of veterinary and animal farming practices. This review explores and compares the various types of gastrointestinal tract models, including static and dynamic systems, and their applications across different animal species. Specific technical and methodological considerations are discussed for core animal-developed and -tested artificial systems and their integration with common ‘omics’ techniques. Dynamic models, such as RUSITEC and PolyFermS, more accurately simulate in vivo processes, including peristalsis, enzymatic activity, and microbial fermentation. The studies employing tools for ‘omics’ approaches have been conducted with more understanding analysis and comprehensive discussion and results.https://www.mdpi.com/2076-2615/15/9/1222artificial gastrointestinal tract modelsveterinarymicrobiota studiesdisease modelingdrug developmenttoxicology assessment |
| spellingShingle | Sergei Konstantinovich Shebeko Heorhii Yurievich Drobot Andrey Georgievich Koshchaev Svetoslav Dimitrov Todorov Alexey Mikhailovich Ermakov Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine Animals artificial gastrointestinal tract models veterinary microbiota studies disease modeling drug development toxicology assessment |
| title | Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine |
| title_full | Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine |
| title_fullStr | Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine |
| title_full_unstemmed | Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine |
| title_short | Application of Artificial Gastrointestinal Tract Models in Veterinary Medicine |
| title_sort | application of artificial gastrointestinal tract models in veterinary medicine |
| topic | artificial gastrointestinal tract models veterinary microbiota studies disease modeling drug development toxicology assessment |
| url | https://www.mdpi.com/2076-2615/15/9/1222 |
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