Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood
We evaluated whether protein restriction in fetal life alters food intake and glucose homeostasis in adulthood by interfering with insulin signal transduction through proinflammatory mechanisms in the hypothalamus and peripheral tissues. Rats were divided into the following: a control group (C); a r...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/736506 |
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| author | Hellen Barbosa Farias Silva Ana Paula Carli de Almeida Katarine Barbosa Cardoso Letícia Martins Ignacio-Souza Silvia Regina de Lima Reis Marise Auxiliadora de Barros Reis Márcia Queiroz Latorraca Marciane Milanski Vanessa Cristina Arantes |
| author_facet | Hellen Barbosa Farias Silva Ana Paula Carli de Almeida Katarine Barbosa Cardoso Letícia Martins Ignacio-Souza Silvia Regina de Lima Reis Marise Auxiliadora de Barros Reis Márcia Queiroz Latorraca Marciane Milanski Vanessa Cristina Arantes |
| author_sort | Hellen Barbosa Farias Silva |
| collection | DOAJ |
| description | We evaluated whether protein restriction in fetal life alters food intake and glucose homeostasis in adulthood by interfering with insulin signal transduction through proinflammatory mechanisms in the hypothalamus and peripheral tissues. Rats were divided into the following: a control group (C); a recovered group (R); and a low protein (LP) group. Relative food intake was greater and serum leptin was diminished in LP and R compared to C rats. Proinflammatory genes and POMC mRNA were upregulated in the hypothalamus of R group. Hypothalamic NPY mRNA expression was greater but AKT phosphorylation was diminished in the LP than in the C rats. In muscle, AKT phosphorylation was higher in restricted than in control animals. The HOMA-IR was decreased in R and C compared to the LP group. In contrast, the Kitt in R was similar to that in C and both were lower than LP rats. Thus, nutritional recovery did not alter glucose homeostasis but produced middle hyperphagia, possibly due to increased anorexigenic neuropeptide expression that counteracted the hypothalamic inflammatory process. In long term protein deprived rats, hyperphagia most likely resulted from increased orexigenic neuropeptide expression, and glucose homeostasis was maintained, at least in part, at the expense of increased muscle insulin sensitivity. |
| format | Article |
| id | doaj-art-39fc6f202d4344a99ad83b07eaef33a1 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-39fc6f202d4344a99ad83b07eaef33a12025-08-20T02:24:13ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/736506736506Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during AdulthoodHellen Barbosa Farias Silva0Ana Paula Carli de Almeida1Katarine Barbosa Cardoso2Letícia Martins Ignacio-Souza3Silvia Regina de Lima Reis4Marise Auxiliadora de Barros Reis5Márcia Queiroz Latorraca6Marciane Milanski7Vanessa Cristina Arantes8Mestrado em Biociências, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiabá, MT, BrazilMestrado em Biociências, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiabá, MT, BrazilLaboratório de Avaliação Biológica de Alimentos, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiabá, MT, BrazilDepartamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Avenida Fernando Correa da Costa, 2367. Bairro Boa Esperança, Cuiabá, MT, BrazilDepartamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Avenida Fernando Correa da Costa, 2367. Bairro Boa Esperança, Cuiabá, MT, BrazilDepartamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Avenida Fernando Correa da Costa, 2367. Bairro Boa Esperança, Cuiabá, MT, BrazilDepartamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Avenida Fernando Correa da Costa, 2367. Bairro Boa Esperança, Cuiabá, MT, BrazilFaculdade de Ciências Aplicadas da Universidade Estadual de Campinas, Campinas, SP, BrazilDepartamento de Alimentos e Nutrição, Faculdade de Nutrição, Universidade Federal de Mato Grosso, Avenida Fernando Correa da Costa, 2367. Bairro Boa Esperança, Cuiabá, MT, BrazilWe evaluated whether protein restriction in fetal life alters food intake and glucose homeostasis in adulthood by interfering with insulin signal transduction through proinflammatory mechanisms in the hypothalamus and peripheral tissues. Rats were divided into the following: a control group (C); a recovered group (R); and a low protein (LP) group. Relative food intake was greater and serum leptin was diminished in LP and R compared to C rats. Proinflammatory genes and POMC mRNA were upregulated in the hypothalamus of R group. Hypothalamic NPY mRNA expression was greater but AKT phosphorylation was diminished in the LP than in the C rats. In muscle, AKT phosphorylation was higher in restricted than in control animals. The HOMA-IR was decreased in R and C compared to the LP group. In contrast, the Kitt in R was similar to that in C and both were lower than LP rats. Thus, nutritional recovery did not alter glucose homeostasis but produced middle hyperphagia, possibly due to increased anorexigenic neuropeptide expression that counteracted the hypothalamic inflammatory process. In long term protein deprived rats, hyperphagia most likely resulted from increased orexigenic neuropeptide expression, and glucose homeostasis was maintained, at least in part, at the expense of increased muscle insulin sensitivity.http://dx.doi.org/10.1155/2014/736506 |
| spellingShingle | Hellen Barbosa Farias Silva Ana Paula Carli de Almeida Katarine Barbosa Cardoso Letícia Martins Ignacio-Souza Silvia Regina de Lima Reis Marise Auxiliadora de Barros Reis Márcia Queiroz Latorraca Marciane Milanski Vanessa Cristina Arantes Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood Mediators of Inflammation |
| title | Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood |
| title_full | Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood |
| title_fullStr | Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood |
| title_full_unstemmed | Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood |
| title_short | Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood |
| title_sort | nutritional recovery promotes hypothalamic inflammation in rats during adulthood |
| url | http://dx.doi.org/10.1155/2014/736506 |
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