Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction
Abstract Thyroid dysfunction is commonly seen in major depressive disorder (MDD), and is particularly prevalent in female patients. Moreover, gender differences occur in many aspects of MDD, including suicide attempts (SAs). We aimed to explore gender differences in the prevalence and clinical corre...
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| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-024-06332-8 |
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| author | Luyu Liu Jian Zhou Xinran Song Guowei Luo Min Peng Xiangyang Zhang |
| author_facet | Luyu Liu Jian Zhou Xinran Song Guowei Luo Min Peng Xiangyang Zhang |
| author_sort | Luyu Liu |
| collection | DOAJ |
| description | Abstract Thyroid dysfunction is commonly seen in major depressive disorder (MDD), and is particularly prevalent in female patients. Moreover, gender differences occur in many aspects of MDD, including suicide attempts (SAs). We aimed to explore gender differences in the prevalence and clinical correlates of SAs in young first-episode drug-naïve MDD patients with thyroid dysfunction, which have not yet been reported. We recruited 509 patients in this study. Demographic and clinical characteristics were collected. We used HAMD-17, HAMA-14, the positive subscale of PANSS, and CGI-S to assess every participant. We found no significant difference in the prevalence of SAs between male and female subgroup. Gender differences in factors associated with SAs were found with anxiety, body mass index, serum anti-thyroid antibodies (A-TPO), and free triiodothyronine levels in male patients and anxiety, CGI-S score, and A-TPO in female patients. We found no gender differences in the prevalence of SAs; however, there were gender differences in several clinical correlates of SAs, highlighting specific strategies to avoid SAs in male and female MDD patients. |
| format | Article |
| id | doaj-art-39fc5cf60e014edb9967f30be6d69d40 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-39fc5cf60e014edb9967f30be6d69d402024-12-08T12:39:43ZengBMCBMC Psychiatry1471-244X2024-12-0124111110.1186/s12888-024-06332-8Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunctionLuyu Liu0Jian Zhou1Xinran Song2Guowei Luo3Min Peng4Xiangyang Zhang5Department of Psychiatry, Shenzhen Nanshan People’s HospitalDepartment of Psychiatry, Shenzhen Nanshan People’s HospitalDepartment of Psychiatry, Shenzhen Nanshan People’s HospitalDepartment of Psychiatry, Shenzhen Nanshan People’s HospitalDepartment of Psychiatry, Shenzhen Nanshan People’s HospitalCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of SciencesAbstract Thyroid dysfunction is commonly seen in major depressive disorder (MDD), and is particularly prevalent in female patients. Moreover, gender differences occur in many aspects of MDD, including suicide attempts (SAs). We aimed to explore gender differences in the prevalence and clinical correlates of SAs in young first-episode drug-naïve MDD patients with thyroid dysfunction, which have not yet been reported. We recruited 509 patients in this study. Demographic and clinical characteristics were collected. We used HAMD-17, HAMA-14, the positive subscale of PANSS, and CGI-S to assess every participant. We found no significant difference in the prevalence of SAs between male and female subgroup. Gender differences in factors associated with SAs were found with anxiety, body mass index, serum anti-thyroid antibodies (A-TPO), and free triiodothyronine levels in male patients and anxiety, CGI-S score, and A-TPO in female patients. We found no gender differences in the prevalence of SAs; however, there were gender differences in several clinical correlates of SAs, highlighting specific strategies to avoid SAs in male and female MDD patients.https://doi.org/10.1186/s12888-024-06332-8Major depressive disorderSuicide attemptsGender differencesFirst episode and drug naïve patients |
| spellingShingle | Luyu Liu Jian Zhou Xinran Song Guowei Luo Min Peng Xiangyang Zhang Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction BMC Psychiatry Major depressive disorder Suicide attempts Gender differences First episode and drug naïve patients |
| title | Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction |
| title_full | Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction |
| title_fullStr | Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction |
| title_full_unstemmed | Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction |
| title_short | Gender differences in the prevalence and clinical correlates of suicide attempts in young first-episode drug-naïve major depressive disorder patients with thyroid dysfunction |
| title_sort | gender differences in the prevalence and clinical correlates of suicide attempts in young first episode drug naive major depressive disorder patients with thyroid dysfunction |
| topic | Major depressive disorder Suicide attempts Gender differences First episode and drug naïve patients |
| url | https://doi.org/10.1186/s12888-024-06332-8 |
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