The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus
Background: Prepubertal girls are one of the vulnerable populations of vulvar lichen sclerosus (VLS), which results in a decreased quality of life and increases risk of vulvar cancer. But the therapeutic effects of traditional topical remedies are unsatisfactory in some pediatric patients. 5-Aminole...
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024000255 |
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| author | Shan Zhang Yukun Wang Juncheng Wang Jie Liu |
| author_facet | Shan Zhang Yukun Wang Juncheng Wang Jie Liu |
| author_sort | Shan Zhang |
| collection | DOAJ |
| description | Background: Prepubertal girls are one of the vulnerable populations of vulvar lichen sclerosus (VLS), which results in a decreased quality of life and increases risk of vulvar cancer. But the therapeutic effects of traditional topical remedies are unsatisfactory in some pediatric patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for refractory VLS patients, but no study has been conducted in child patients. Methods: The patients included in this study underwent three sessions of ALA-PDT at 2-week intervals. All patients were evaluated for objective clinical appearances and subjective symptoms quantitatively. Statistical analysis comparing parameters at baseline and after three-time ALA-PDT was performed. Results: A total of seven VLS girl patients were included in this study. Both primary objective appearances (lesion size and depigmentation) and subjective symptoms (itching and burning pain) were improved remarkably after the third treatment. Besides, adverse effects, mainly as pain and post-treatment edema, were mild and could be tolerated. Conclusions: ALA-PDT is an effective and safe therapeutic option for VLS girl patients. Compared with adult patients, the symptoms resolved more quickly in child patients. |
| format | Article |
| id | doaj-art-39f607a1d35941b6bb0da8a29c4b7b63 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-39f607a1d35941b6bb0da8a29c4b7b632025-08-20T02:39:02ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510398610.1016/j.pdpdt.2024.103986The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosusShan Zhang0Yukun Wang1Juncheng Wang2Jie Liu3Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, PR ChinaDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, PR ChinaDepartment of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, PR ChinaCorresponding author at: Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, PR China.; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, PR ChinaBackground: Prepubertal girls are one of the vulnerable populations of vulvar lichen sclerosus (VLS), which results in a decreased quality of life and increases risk of vulvar cancer. But the therapeutic effects of traditional topical remedies are unsatisfactory in some pediatric patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for refractory VLS patients, but no study has been conducted in child patients. Methods: The patients included in this study underwent three sessions of ALA-PDT at 2-week intervals. All patients were evaluated for objective clinical appearances and subjective symptoms quantitatively. Statistical analysis comparing parameters at baseline and after three-time ALA-PDT was performed. Results: A total of seven VLS girl patients were included in this study. Both primary objective appearances (lesion size and depigmentation) and subjective symptoms (itching and burning pain) were improved remarkably after the third treatment. Besides, adverse effects, mainly as pain and post-treatment edema, were mild and could be tolerated. Conclusions: ALA-PDT is an effective and safe therapeutic option for VLS girl patients. Compared with adult patients, the symptoms resolved more quickly in child patients.http://www.sciencedirect.com/science/article/pii/S1572100024000255Vulvar lichen sclerosusPediatric5-aminolevulinic acid photodynamic therapyTreatment assessment |
| spellingShingle | Shan Zhang Yukun Wang Juncheng Wang Jie Liu The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus Photodiagnosis and Photodynamic Therapy Vulvar lichen sclerosus Pediatric 5-aminolevulinic acid photodynamic therapy Treatment assessment |
| title | The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus |
| title_full | The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus |
| title_fullStr | The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus |
| title_full_unstemmed | The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus |
| title_short | The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus |
| title_sort | efficacy of 5 aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus |
| topic | Vulvar lichen sclerosus Pediatric 5-aminolevulinic acid photodynamic therapy Treatment assessment |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024000255 |
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