Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023
We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. The...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-02-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/2/24-0831_article |
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| author | Charles Y. Chiu Raja Rama Godasi Holly R. Hughes Venice Servellita Kafaya Foresythe Asritha Tubati Kelsey Zorn Sukhman Sidhu Michael R. Wilson Sai Varun Bethina Daniel Abenroth Yee Cheng Raymond Grams Camilla Reese Carlos Isada Neeharika Thottempudi |
| author_facet | Charles Y. Chiu Raja Rama Godasi Holly R. Hughes Venice Servellita Kafaya Foresythe Asritha Tubati Kelsey Zorn Sukhman Sidhu Michael R. Wilson Sai Varun Bethina Daniel Abenroth Yee Cheng Raymond Grams Camilla Reese Carlos Isada Neeharika Thottempudi |
| author_sort | Charles Y. Chiu |
| collection | DOAJ |
| description |
We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. These findings highlight the power of metagenomic next-generation sequencing in broad-based, agnostic detection of emerging viral infections that test negative using conventional targeted diagnostic methods.
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| format | Article |
| id | doaj-art-39f5f92f6907465a95e830ea11263be8 |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-39f5f92f6907465a95e830ea11263be82025-08-20T02:14:57ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-02-0131221522110.3201/eid3102.240831Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023Charles Y. ChiuRaja Rama GodasiHolly R. HughesVenice ServellitaKafaya ForesytheAsritha TubatiKelsey ZornSukhman SidhuMichael R. WilsonSai Varun BethinaDaniel AbenrothYee ChengRaymond GramsCamilla ReeseCarlos IsadaNeeharika Thottempudi We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. These findings highlight the power of metagenomic next-generation sequencing in broad-based, agnostic detection of emerging viral infections that test negative using conventional targeted diagnostic methods. https://wwwnc.cdc.gov/eid/article/31/2/24-0831_articlePotosi virusLone Star virusvirusesbunyavirusPOTVLSV |
| spellingShingle | Charles Y. Chiu Raja Rama Godasi Holly R. Hughes Venice Servellita Kafaya Foresythe Asritha Tubati Kelsey Zorn Sukhman Sidhu Michael R. Wilson Sai Varun Bethina Daniel Abenroth Yee Cheng Raymond Grams Camilla Reese Carlos Isada Neeharika Thottempudi Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 Emerging Infectious Diseases Potosi virus Lone Star virus viruses bunyavirus POTV LSV |
| title | Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 |
| title_full | Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 |
| title_fullStr | Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 |
| title_full_unstemmed | Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 |
| title_short | Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 |
| title_sort | two human cases of fatal meningoencephalitis associated with potosi and lone star virus infections united states 2020 2023 |
| topic | Potosi virus Lone Star virus viruses bunyavirus POTV LSV |
| url | https://wwwnc.cdc.gov/eid/article/31/2/24-0831_article |
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