Image quality evaluation for two different positron emitters in a preclinical PET scanner
Positron emission tomography (PET) is widely used in preclinical trials, generating molecular images applied to biochemical, metabolic and functional investigation of organs and tissues. The positron emitters 11C and 18F radionuclides are relevant for different diseases studies. However, they have d...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2020-09-01
|
| Series: | Brazilian Journal of Radiation Sciences |
| Subjects: | |
| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/1299 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849423872487587840 |
|---|---|
| author | Rodrigo Modesto Gadelha Andréa Vidal Ferreira Guilherme Albuquerque Cavalcante Souza Juliana Batista Silva Marcelo Mamede |
| author_facet | Rodrigo Modesto Gadelha Andréa Vidal Ferreira Guilherme Albuquerque Cavalcante Souza Juliana Batista Silva Marcelo Mamede |
| author_sort | Rodrigo Modesto Gadelha |
| collection | DOAJ |
| description | Positron emission tomography (PET) is widely used in preclinical trials, generating molecular images applied to biochemical, metabolic and functional investigation of organs and tissues. The positron emitters 11C and 18F radionuclides are relevant for different diseases studies. However, they have different positron energies, ranges, and branching ratio. This could result in a distinct quality between the acquired PET images. Thus, the aim of this study is to evaluate the image quality performance of the PET scanner (LabPET 4, GE) at CDTN/CNEN using the NEMA NU 4-2008 standards and specific phantom for these two different positron emitters. The NEMA image-quality (IQ) phantom consists of 3 different regions to analyze distinct characteristics: uniformity, recovery coefficients (RCs) and spill-over rations (SOR) in air and water. The IQ phantom was filled with two different aqueous solutions (18F-FDG and 11C-PK11195), both activities calibrated at the beginning of acquisition (3.7MBq). The IQ phantom was placed in the center of the field-of-view (FOV) and measured with the typical whole body imaging protocol. The images were reconstructed following the Molecular Imaging Laboratory (LIM/CDTN) standard protocol: MLEM-3D algorithm, 20 iterations, no high-resolution mode, no attenuation or scatter corrections, no post-filtering. PMOD® software was used to perform images post-processing following NEMA analyses standard. The %SD of medium concentration activity for 18F and 11C was 7.7 and 14.5, respectively. The RCs for 18F and 11C were 0.11 and 0.12 respectively for the 1-mm-diameter rod and 0.88 and 0.77 for the 5-mm-diameter rod. SORs in air were 0.19 and 0.22, respectively, and in water 0.29 and 0.33. Experimental results demonstrates that when 18F radionuclide is used, PET images presents a better performance in the image quality tests compared to 11C PET images. |
| format | Article |
| id | doaj-art-39f4f2b997844ed09a03aa1c36f0b92c |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-39f4f2b997844ed09a03aa1c36f0b92c2025-08-20T03:30:25ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122020-09-018310.15392/bjrs.v8i3.12991010Image quality evaluation for two different positron emitters in a preclinical PET scannerRodrigo Modesto Gadelha0Andréa Vidal Ferreira1Guilherme Albuquerque Cavalcante Souza2Juliana Batista Silva3Marcelo Mamede4Federal University of Minas GeraisCDTNUFMG and CDTNCDTN/CNEN.UFMGPositron emission tomography (PET) is widely used in preclinical trials, generating molecular images applied to biochemical, metabolic and functional investigation of organs and tissues. The positron emitters 11C and 18F radionuclides are relevant for different diseases studies. However, they have different positron energies, ranges, and branching ratio. This could result in a distinct quality between the acquired PET images. Thus, the aim of this study is to evaluate the image quality performance of the PET scanner (LabPET 4, GE) at CDTN/CNEN using the NEMA NU 4-2008 standards and specific phantom for these two different positron emitters. The NEMA image-quality (IQ) phantom consists of 3 different regions to analyze distinct characteristics: uniformity, recovery coefficients (RCs) and spill-over rations (SOR) in air and water. The IQ phantom was filled with two different aqueous solutions (18F-FDG and 11C-PK11195), both activities calibrated at the beginning of acquisition (3.7MBq). The IQ phantom was placed in the center of the field-of-view (FOV) and measured with the typical whole body imaging protocol. The images were reconstructed following the Molecular Imaging Laboratory (LIM/CDTN) standard protocol: MLEM-3D algorithm, 20 iterations, no high-resolution mode, no attenuation or scatter corrections, no post-filtering. PMOD® software was used to perform images post-processing following NEMA analyses standard. The %SD of medium concentration activity for 18F and 11C was 7.7 and 14.5, respectively. The RCs for 18F and 11C were 0.11 and 0.12 respectively for the 1-mm-diameter rod and 0.88 and 0.77 for the 5-mm-diameter rod. SORs in air were 0.19 and 0.22, respectively, and in water 0.29 and 0.33. Experimental results demonstrates that when 18F radionuclide is used, PET images presents a better performance in the image quality tests compared to 11C PET images.https://bjrs.org.br/revista/index.php/REVISTA/article/view/1299image qualitypreclinical pet scannertwo positron emittersnema nu 4-2008 |
| spellingShingle | Rodrigo Modesto Gadelha Andréa Vidal Ferreira Guilherme Albuquerque Cavalcante Souza Juliana Batista Silva Marcelo Mamede Image quality evaluation for two different positron emitters in a preclinical PET scanner Brazilian Journal of Radiation Sciences image quality preclinical pet scanner two positron emitters nema nu 4-2008 |
| title | Image quality evaluation for two different positron emitters in a preclinical PET scanner |
| title_full | Image quality evaluation for two different positron emitters in a preclinical PET scanner |
| title_fullStr | Image quality evaluation for two different positron emitters in a preclinical PET scanner |
| title_full_unstemmed | Image quality evaluation for two different positron emitters in a preclinical PET scanner |
| title_short | Image quality evaluation for two different positron emitters in a preclinical PET scanner |
| title_sort | image quality evaluation for two different positron emitters in a preclinical pet scanner |
| topic | image quality preclinical pet scanner two positron emitters nema nu 4-2008 |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/1299 |
| work_keys_str_mv | AT rodrigomodestogadelha imagequalityevaluationfortwodifferentpositronemittersinapreclinicalpetscanner AT andreavidalferreira imagequalityevaluationfortwodifferentpositronemittersinapreclinicalpetscanner AT guilhermealbuquerquecavalcantesouza imagequalityevaluationfortwodifferentpositronemittersinapreclinicalpetscanner AT julianabatistasilva imagequalityevaluationfortwodifferentpositronemittersinapreclinicalpetscanner AT marcelomamede imagequalityevaluationfortwodifferentpositronemittersinapreclinicalpetscanner |