Antibiotic Considerations in the Treatment of Maternal Sepsis
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains the third leading cause of maternal mortality globally. Pregnancy-associated physiological adaptations predispose pregnant individuals to infection, impair maternal response to infection, affect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/4/387 |
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| author | Sarah E. White R. Phillips Heine Talla M. Widelock |
| author_facet | Sarah E. White R. Phillips Heine Talla M. Widelock |
| author_sort | Sarah E. White |
| collection | DOAJ |
| description | Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains the third leading cause of maternal mortality globally. Pregnancy-associated physiological adaptations predispose pregnant individuals to infection, impair maternal response to infection, affect antibiotic pharmacokinetics and metabolism, and complicate diagnosing infections and sepsis. Therefore, it is tantamount that clinicians readily recognize maternal sepsis and understand antibiotic regimens and treatment principles to avoid adverse maternal outcomes. In this article, we present an overview of the diagnosis and management of maternal sepsis and the physiological changes in pregnancy that alter antibiotic pharmacokinetics. Common microorganisms implicated in maternal sepsis are discussed with an emphasis on <i>E. coli</i> and Group A <i>Streptococcus</i> due to their prevalence and morbidity in the pregnant population. Lastly, we provide an overview of commonly used antibiotics and dosage recommendations in the treatment of maternal infection and sepsis. |
| format | Article |
| id | doaj-art-39f456f16d324747a7f7ea0548dd0123 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-39f456f16d324747a7f7ea0548dd01232025-08-20T02:17:25ZengMDPI AGAntibiotics2079-63822025-04-0114438710.3390/antibiotics14040387Antibiotic Considerations in the Treatment of Maternal SepsisSarah E. White0R. Phillips Heine1Talla M. Widelock2Department of Obstetrics Gynecology, Section of Maternal Fetal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USADepartment of Obstetrics Gynecology, Section of Maternal Fetal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USADepartment of Obstetrics Gynecology, Section of Maternal Fetal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USASepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains the third leading cause of maternal mortality globally. Pregnancy-associated physiological adaptations predispose pregnant individuals to infection, impair maternal response to infection, affect antibiotic pharmacokinetics and metabolism, and complicate diagnosing infections and sepsis. Therefore, it is tantamount that clinicians readily recognize maternal sepsis and understand antibiotic regimens and treatment principles to avoid adverse maternal outcomes. In this article, we present an overview of the diagnosis and management of maternal sepsis and the physiological changes in pregnancy that alter antibiotic pharmacokinetics. Common microorganisms implicated in maternal sepsis are discussed with an emphasis on <i>E. coli</i> and Group A <i>Streptococcus</i> due to their prevalence and morbidity in the pregnant population. Lastly, we provide an overview of commonly used antibiotics and dosage recommendations in the treatment of maternal infection and sepsis.https://www.mdpi.com/2079-6382/14/4/387maternal sepsissepsispregnancy physiologyantibiotics |
| spellingShingle | Sarah E. White R. Phillips Heine Talla M. Widelock Antibiotic Considerations in the Treatment of Maternal Sepsis Antibiotics maternal sepsis sepsis pregnancy physiology antibiotics |
| title | Antibiotic Considerations in the Treatment of Maternal Sepsis |
| title_full | Antibiotic Considerations in the Treatment of Maternal Sepsis |
| title_fullStr | Antibiotic Considerations in the Treatment of Maternal Sepsis |
| title_full_unstemmed | Antibiotic Considerations in the Treatment of Maternal Sepsis |
| title_short | Antibiotic Considerations in the Treatment of Maternal Sepsis |
| title_sort | antibiotic considerations in the treatment of maternal sepsis |
| topic | maternal sepsis sepsis pregnancy physiology antibiotics |
| url | https://www.mdpi.com/2079-6382/14/4/387 |
| work_keys_str_mv | AT sarahewhite antibioticconsiderationsinthetreatmentofmaternalsepsis AT rphillipsheine antibioticconsiderationsinthetreatmentofmaternalsepsis AT tallamwidelock antibioticconsiderationsinthetreatmentofmaternalsepsis |