Bacteriophage Therapy on an In Vitro Wound Model and Synergistic Effects in Combination with Beta-Lactam Antibiotics

Bacteriophage Therapy on an In Vitro Wound Model and Synergistic Effects in Combination with Beta-Lactam Antibiotics

One of the primary opportunistic pathogens that can cause a wide range of diseases is <i>Pseudomonas aeruginosa</i>. This microorganism can become resistant to practically every antibacterial currently in use, including beta-lactam antibiotics. Its ability to proliferate as biofilm has b...

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Bibliographic Details
Main Authors: Guillermo Santamaría-Corral, John Jairo Aguilera-Correa, Jaime Esteban, Meritxell García-Quintanilla
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Antibiotics
Subjects:
bacteriophage
<i>Pseudomonas aeruginosa</i>
multi-drug resistance
beta-lactam
wound infection
Online Access:https://www.mdpi.com/2079-6382/13/9/800
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Summary:One of the primary opportunistic pathogens that can cause a wide range of diseases is <i>Pseudomonas aeruginosa</i>. This microorganism can become resistant to practically every antibacterial currently in use, including beta-lactam antibiotics. Its ability to proliferate as biofilm has been linked to, among other things, the failure of antimicrobial therapies. Due to a variety of virulence factors and host immune system modifications, <i>P. aeruginosa</i> is one of the most significant and common bacteria that colonize wounds and burns. A novel therapeutic option for treating these multidrug-resistant (MDR) bacterial infections is the combination of antibiotics and bacteriophages. This approach has been linked to improved biofilm penetration, a decreased selection of antibiotic and bacteriophage resistance, and an enhanced antibacterial impact. Combining the F1Pa bacteriophage and beta-lactam antibiotics reduced the viability of the mature biofilm of MDR <i>P. aeruginosa</i> strains and suppressed bacterial growth in vitro. F1Pa critically reduced the amount of biofilm that MDR <i>P. aeruginosa</i> clinical strains formed in the in vitro wound model. These findings highlight the bacteriophage F1Pa’s therapeutic potential as a prophylactic topical treatment against MDR pseudomonal infections in wounds and burns.
ISSN:2079-6382

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