Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review
Abstract Catecholamines, essential neurotransmitters and hormones, play a critical role in the body’s physiological response to stress and are pivotal in the management of various clinical conditions, particularly in critical care settings. This narrative review delves into the pharmacological prope...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Anesthesia, Analgesia and Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s44158-025-00241-2 |
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| author | Jacopo Belfiore Riccardo Taddei Giandomenico Biancofiore |
| author_facet | Jacopo Belfiore Riccardo Taddei Giandomenico Biancofiore |
| author_sort | Jacopo Belfiore |
| collection | DOAJ |
| description | Abstract Catecholamines, essential neurotransmitters and hormones, play a critical role in the body’s physiological response to stress and are pivotal in the management of various clinical conditions, particularly in critical care settings. This narrative review delves into the pharmacological properties of catecholamines, including their mechanisms of action, pharmacokinetics, and pharmacodynamics. Key clinical applications of catecholamines, especially in the cardiovascular and immune systems, are highlighted, emphasizing their roles in modulating heart rate, vascular tone, and immune responses during critical conditions such as sepsis and septic shock. Additionally, the review explores catecholamines’ immunomodulatory effects and their interactions with other therapeutic agents, such as corticosteroids, in the management of septic shock. Further research is suggested to optimize catecholamine usage and improve patient outcomes in critical care settings. |
| format | Article |
| id | doaj-art-39ef5c279cc649a29cdeebe6d592d2af |
| institution | OA Journals |
| issn | 2731-3786 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Anesthesia, Analgesia and Critical Care |
| spelling | doaj-art-39ef5c279cc649a29cdeebe6d592d2af2025-08-20T01:54:25ZengBMCJournal of Anesthesia, Analgesia and Critical Care2731-37862025-04-01511910.1186/s44158-025-00241-2Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative reviewJacopo Belfiore0Riccardo Taddei1Giandomenico Biancofiore2Anesthesia and Transplant Intensive Care Unit, Department of Anesthesiology and Intensive Care, University of PisaAnesthesia and Transplant Intensive Care Unit, Department of Anesthesiology and Intensive Care, University of PisaAnesthesia and Transplant Intensive Care Unit, Department of Anesthesiology and Intensive Care, University of PisaAbstract Catecholamines, essential neurotransmitters and hormones, play a critical role in the body’s physiological response to stress and are pivotal in the management of various clinical conditions, particularly in critical care settings. This narrative review delves into the pharmacological properties of catecholamines, including their mechanisms of action, pharmacokinetics, and pharmacodynamics. Key clinical applications of catecholamines, especially in the cardiovascular and immune systems, are highlighted, emphasizing their roles in modulating heart rate, vascular tone, and immune responses during critical conditions such as sepsis and septic shock. Additionally, the review explores catecholamines’ immunomodulatory effects and their interactions with other therapeutic agents, such as corticosteroids, in the management of septic shock. Further research is suggested to optimize catecholamine usage and improve patient outcomes in critical care settings.https://doi.org/10.1186/s44158-025-00241-2Adrenergic receptorsToll-like receptorsCytokinesEndothelial dysfunctionImmunomodulatory effectCorticosteroids |
| spellingShingle | Jacopo Belfiore Riccardo Taddei Giandomenico Biancofiore Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review Journal of Anesthesia, Analgesia and Critical Care Adrenergic receptors Toll-like receptors Cytokines Endothelial dysfunction Immunomodulatory effect Corticosteroids |
| title | Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review |
| title_full | Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review |
| title_fullStr | Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review |
| title_full_unstemmed | Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review |
| title_short | Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review |
| title_sort | catecholamines in sepsis pharmacological insights and clinical applications a narrative review |
| topic | Adrenergic receptors Toll-like receptors Cytokines Endothelial dysfunction Immunomodulatory effect Corticosteroids |
| url | https://doi.org/10.1186/s44158-025-00241-2 |
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