Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats
Aims. The aim of this study was to compare the phytochemical profile and acute and chronic toxicity of hydroethanolic extracts of three parts of P. santalinoides. Methods. Seven major chemical groups (alkaloids, flavonoids, saponosides, coumarins, tannins, triterpenes, and steroids) were studied. Th...
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2022-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/5953094 |
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| author | Aimé Cézaire T. Ayéna Kossivi Dosseh Kokou Idoh Amegnona Agbonon Messanvi Gbeassor |
| author_facet | Aimé Cézaire T. Ayéna Kossivi Dosseh Kokou Idoh Amegnona Agbonon Messanvi Gbeassor |
| author_sort | Aimé Cézaire T. Ayéna |
| collection | DOAJ |
| description | Aims. The aim of this study was to compare the phytochemical profile and acute and chronic toxicity of hydroethanolic extracts of three parts of P. santalinoides. Methods. Seven major chemical groups (alkaloids, flavonoids, saponosides, coumarins, tannins, triterpenes, and steroids) were studied. The single dose limit test of 5000 mg/kg body weight was used to evaluate the acute toxicity of each organic extract. Subacute toxicity was evaluated after daily oral doses of 500 and 1000 mg/kg body weight were administered to rats for 28 days. Results. At a single dose of 5000 mg/kg, none of the extracts (leaf, trunk bark, and root) caused death in experimental rats. However, the trunk bark extract of P. santalinoides induced coat change and lethargy in treated rats. Macroscopic observation of the internal organs (liver and kidneys) of the rats showed no abnormalities. In the subacute test, only the trunk extracts induced signs of toxicity such as mobility disorders, diarrhea, and loss of body weight at a dose of 1000 mg/kg. Conclusion. This study showed that the hydroethanol extracts of the leaves, trunk bark, and root bark of P. santalinoides divergently concentrated the main chemical groups of interest. Administration of a single dose of extracts from all three P. santalinoides is not toxic to the consumer. However, when used over a long period of time, they can have a harmful effect on the consumer. In view of the different results of the trunk bark extract and in a context of conservation of the species, we recommend the use of the hydroethanolic extract of the leaves in the different treatments in which the three organs are involved. |
| format | Article |
| id | doaj-art-39e4398d01a549c4b45c681ea43d13ed |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-39e4398d01a549c4b45c681ea43d13ed2025-08-20T03:35:50ZengWileyThe Scientific World Journal1537-744X2022-01-01202210.1155/2022/5953094Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar RatsAimé Cézaire T. Ayéna0Kossivi Dosseh1Kokou Idoh2Amegnona Agbonon3Messanvi Gbeassor4Faculty of Sciences and Techniques of the University of Abomey-CalaviMedicinal Plants Research and Training Center (CERFOPLAM)Medicinal Plants Research and Training Center (CERFOPLAM)Medicinal Plants Research and Training Center (CERFOPLAM)Medicinal Plants Research and Training Center (CERFOPLAM)Aims. The aim of this study was to compare the phytochemical profile and acute and chronic toxicity of hydroethanolic extracts of three parts of P. santalinoides. Methods. Seven major chemical groups (alkaloids, flavonoids, saponosides, coumarins, tannins, triterpenes, and steroids) were studied. The single dose limit test of 5000 mg/kg body weight was used to evaluate the acute toxicity of each organic extract. Subacute toxicity was evaluated after daily oral doses of 500 and 1000 mg/kg body weight were administered to rats for 28 days. Results. At a single dose of 5000 mg/kg, none of the extracts (leaf, trunk bark, and root) caused death in experimental rats. However, the trunk bark extract of P. santalinoides induced coat change and lethargy in treated rats. Macroscopic observation of the internal organs (liver and kidneys) of the rats showed no abnormalities. In the subacute test, only the trunk extracts induced signs of toxicity such as mobility disorders, diarrhea, and loss of body weight at a dose of 1000 mg/kg. Conclusion. This study showed that the hydroethanol extracts of the leaves, trunk bark, and root bark of P. santalinoides divergently concentrated the main chemical groups of interest. Administration of a single dose of extracts from all three P. santalinoides is not toxic to the consumer. However, when used over a long period of time, they can have a harmful effect on the consumer. In view of the different results of the trunk bark extract and in a context of conservation of the species, we recommend the use of the hydroethanolic extract of the leaves in the different treatments in which the three organs are involved.http://dx.doi.org/10.1155/2022/5953094 |
| spellingShingle | Aimé Cézaire T. Ayéna Kossivi Dosseh Kokou Idoh Amegnona Agbonon Messanvi Gbeassor Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats The Scientific World Journal |
| title | Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats |
| title_full | Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats |
| title_fullStr | Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats |
| title_full_unstemmed | Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats |
| title_short | Comparative Physicochemical Screening and Toxicology of Hydroethanol Extracts of the Parts of Pterocarpus santalinoides l’Hér. ex DC. (Fabaceae) in Wistar Rats |
| title_sort | comparative physicochemical screening and toxicology of hydroethanol extracts of the parts of pterocarpus santalinoides l her ex dc fabaceae in wistar rats |
| url | http://dx.doi.org/10.1155/2022/5953094 |
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