Oxidative Stress in Patients With Nongenital Warts
Comparison of oxidative stress status between subjects with or without warts is absent in the literature. In this study, we evaluated 31 consecutive patients with warts (15 female, 16 male) and 36 control cases with no evidence of disease to determine the effects of oxidative stress in patients with...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.233 |
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| _version_ | 1832566808904728576 |
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| author | Sezai Sasmaz Ozer Arican Ergul Belge Kurutas |
| author_facet | Sezai Sasmaz Ozer Arican Ergul Belge Kurutas |
| author_sort | Sezai Sasmaz |
| collection | DOAJ |
| description | Comparison of oxidative stress status between subjects with or without warts is absent in the literature. In this study, we evaluated 31 consecutive patients with warts (15 female, 16 male) and 36 control cases with no evidence of disease to determine the effects of oxidative stress in patients with warts. The patients were classified according to the wart type, duration, number, and location of lesions. We measured the indicators of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood by spectrophotometry. There was a statistically significant increase in levels of CAT, G6PD, SOD activities and MDA in the patients with warts compared to the control group (P<.05). However, we could not define a statistically significant correlation between these increased enzyme activities and MDA levels and the type, the duration, the number, and the location of lesions. We determined possible suppression of T cells during oxidative stress that might have a negative effect on the prognosis of the disease. Therefore, we propose an argument for the appropriateness to give priority to immunomodulatory treatment alternatives instead of destructive methods in patients with demonstrated oxidative stress. |
| format | Article |
| id | doaj-art-39e1e230c9464358b435e776a54def1a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-39e1e230c9464358b435e776a54def1a2025-02-03T01:02:59ZengWileyMediators of Inflammation0962-93511466-18612005-01-012005423323610.1155/MI.2005.233Oxidative Stress in Patients With Nongenital WartsSezai Sasmaz0Ozer Arican1Ergul Belge Kurutas2Department of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Biochemistry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras 46050, TurkeyComparison of oxidative stress status between subjects with or without warts is absent in the literature. In this study, we evaluated 31 consecutive patients with warts (15 female, 16 male) and 36 control cases with no evidence of disease to determine the effects of oxidative stress in patients with warts. The patients were classified according to the wart type, duration, number, and location of lesions. We measured the indicators of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood by spectrophotometry. There was a statistically significant increase in levels of CAT, G6PD, SOD activities and MDA in the patients with warts compared to the control group (P<.05). However, we could not define a statistically significant correlation between these increased enzyme activities and MDA levels and the type, the duration, the number, and the location of lesions. We determined possible suppression of T cells during oxidative stress that might have a negative effect on the prognosis of the disease. Therefore, we propose an argument for the appropriateness to give priority to immunomodulatory treatment alternatives instead of destructive methods in patients with demonstrated oxidative stress.http://dx.doi.org/10.1155/MI.2005.233 |
| spellingShingle | Sezai Sasmaz Ozer Arican Ergul Belge Kurutas Oxidative Stress in Patients With Nongenital Warts Mediators of Inflammation |
| title | Oxidative Stress in Patients With Nongenital Warts |
| title_full | Oxidative Stress in Patients With Nongenital Warts |
| title_fullStr | Oxidative Stress in Patients With Nongenital Warts |
| title_full_unstemmed | Oxidative Stress in Patients With Nongenital Warts |
| title_short | Oxidative Stress in Patients With Nongenital Warts |
| title_sort | oxidative stress in patients with nongenital warts |
| url | http://dx.doi.org/10.1155/MI.2005.233 |
| work_keys_str_mv | AT sezaisasmaz oxidativestressinpatientswithnongenitalwarts AT ozerarican oxidativestressinpatientswithnongenitalwarts AT ergulbelgekurutas oxidativestressinpatientswithnongenitalwarts |