Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.)
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produce...
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Wiley
2024-05-01
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| Online Access: | https://doi.org/10.2903/j.efsa.2024.8797 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Boet Glandorf Montserrat Anguita Matteo Lorenzo Innocenti Elisa Pettenati |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Boet Glandorf Montserrat Anguita Matteo Lorenzo Innocenti Elisa Pettenati |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) as a zootechnical feed additive for all poultry species. The additive is authorised in feed for chickens and turkeys for fattening, ducks and laying hens. In 2020, the FEEDAP Panel issued an opinion for the renewal of the authorisation of the additive for the species/categories for which there is an authorisation, a reduction of the minimum recommended level in turkeys for fattening and the extension of use to all poultry species. In that assessment, the Panel could not conclude on the safety of the additive due to uncertainties on the characterisation of the production strains and the possible presence of their viable cells and DNA in the final product. Moreover, limitations were identified in the xylanase specifications and xylanase method of analysis. The applicant submitted information to address the limitations previously identified. The Panel concluded that the additive is safe for the target species under the proposed conditions of use. The use of Avizyme® 1505 in animal nutrition is considered safe for the consumer and the environment. The additive is a mild irritant to skin and eyes; it is not a dermal sensitiser but should be considered a respiratory sensitiser. The additive is efficacious in ducks at 75 U endo‐1,4‐β‐xylanase, 1000 U subtilisin and 100 U α‐amylase/kg of complete feed. In other poultry species for fattening (including turkeys), reared for breeding and reared for laying, the additive is efficacious at 187.5 U endo‐1,4‐β‐xylanase, 2500 U subtilisin and 250 U α‐amylase per kg of complete feed and at 300 U endo‐1,4‐β‐xylanase, 4000 U subtilisin and 400 U α‐amylase per kg of complete feed for all poultry species for laying (except for ducks). |
| format | Article |
| id | doaj-art-39d51f48596e4dccaa4d326d8db02db0 |
| institution | OA Journals |
| issn | 1831-4732 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-39d51f48596e4dccaa4d326d8db02db02025-08-20T02:09:31ZengWileyEFSA Journal1831-47322024-05-01225n/an/a10.2903/j.efsa.2024.8797Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenMojca DurjavaBirgit DusemundMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosRoberto Edoardo VillaRuud WoutersenBoet GlandorfMontserrat AnguitaMatteo Lorenzo InnocentiElisa PettenatiAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) as a zootechnical feed additive for all poultry species. The additive is authorised in feed for chickens and turkeys for fattening, ducks and laying hens. In 2020, the FEEDAP Panel issued an opinion for the renewal of the authorisation of the additive for the species/categories for which there is an authorisation, a reduction of the minimum recommended level in turkeys for fattening and the extension of use to all poultry species. In that assessment, the Panel could not conclude on the safety of the additive due to uncertainties on the characterisation of the production strains and the possible presence of their viable cells and DNA in the final product. Moreover, limitations were identified in the xylanase specifications and xylanase method of analysis. The applicant submitted information to address the limitations previously identified. The Panel concluded that the additive is safe for the target species under the proposed conditions of use. The use of Avizyme® 1505 in animal nutrition is considered safe for the consumer and the environment. The additive is a mild irritant to skin and eyes; it is not a dermal sensitiser but should be considered a respiratory sensitiser. The additive is efficacious in ducks at 75 U endo‐1,4‐β‐xylanase, 1000 U subtilisin and 100 U α‐amylase/kg of complete feed. In other poultry species for fattening (including turkeys), reared for breeding and reared for laying, the additive is efficacious at 187.5 U endo‐1,4‐β‐xylanase, 2500 U subtilisin and 250 U α‐amylase per kg of complete feed and at 300 U endo‐1,4‐β‐xylanase, 4000 U subtilisin and 400 U α‐amylase per kg of complete feed for all poultry species for laying (except for ducks).https://doi.org/10.2903/j.efsa.2024.8797Avizyme® 1505digestibility enhancerspoultrysafetyzootechnical additives |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Boet Glandorf Montserrat Anguita Matteo Lorenzo Innocenti Elisa Pettenati Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.) EFSA Journal Avizyme® 1505 digestibility enhancers poultry safety zootechnical additives |
| title | Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.) |
| title_full | Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.) |
| title_fullStr | Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.) |
| title_full_unstemmed | Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.) |
| title_short | Safety of the feed additive consisting of endo‐1,4‐β‐xylanase (produced with Trichoderma reesei CBS 143953), subtilisin (produced with Bacillus subtilis CBS 143946) and α‐amylase (produced with Bacillus amyloliquefaciens CBS 143954) (Avizyme® 1505) for all poultry species (Danisco (UK) Ltd.) |
| title_sort | safety of the feed additive consisting of endo 1 4 β xylanase produced with trichoderma reesei cbs 143953 subtilisin produced with bacillus subtilis cbs 143946 and α amylase produced with bacillus amyloliquefaciens cbs 143954 avizyme r 1505 for all poultry species danisco uk ltd |
| topic | Avizyme® 1505 digestibility enhancers poultry safety zootechnical additives |
| url | https://doi.org/10.2903/j.efsa.2024.8797 |
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safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT baltasarmayo safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT alenapechova safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT marianapetkova safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT fernandoramos safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT robertoedoardovilla safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT ruudwoutersen safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT boetglandorf safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT montserratanguita safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT matteolorenzoinnocenti safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd AT elisapettenati safetyofthefeedadditiveconsistingofendo14bxylanaseproducedwithtrichodermareeseicbs143953subtilisinproducedwithbacillussubtiliscbs143946andaamylaseproducedwithbacillusamyloliquefacienscbs143954avizyme1505forallpoultryspeciesdaniscoukltd |