p38δ MAPK: Emerging Roles of a Neglected Isoform
p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its contribution to both physiological and pathologi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/272689 |
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| author | Carol O’Callaghan Liam J. Fanning Orla P. Barry |
| author_facet | Carol O’Callaghan Liam J. Fanning Orla P. Barry |
| author_sort | Carol O’Callaghan |
| collection | DOAJ |
| description | p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its contribution to both physiological and pathological conditions are presently lacking. Recent emerging evidence, however, provides some insights into specific p38δ MAPK signalling. Importantly, these studies have helped to highlight functional similarities as well as differences between p38δ MAPK and the other members of the p38 MAPK family of kinases. In this review we discuss the current understanding of the molecular mechanisms underlying p38δ MAPK activity. We outline a role for p38δ MAPK in important cellular processes such as differentiation and apoptosis as well as pathological conditions such as neurodegenerative disorders, diabetes, and inflammatory disease. Interestingly, disparate roles for p38δ MAPK in tumour development have also recently been reported. Thus, we consider evidence which characterises p38δ MAPK as both a tumour promoter and a tumour suppressor. In summary, while our knowledge of p38δ MAPK has progressed somewhat since its identification in 1997, our understanding of this particular isoform in many cellular processes still strikingly lags behind that of its counterparts. |
| format | Article |
| id | doaj-art-39d13a1328aa44b4b7ecc6df073e6b6b |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-39d13a1328aa44b4b7ecc6df073e6b6b2025-02-03T06:07:29ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/272689272689p38δ MAPK: Emerging Roles of a Neglected IsoformCarol O’Callaghan0Liam J. Fanning1Orla P. Barry2Department of Pharmacology and Therapeutics, Western Gateway Building, Western Road, University College Cork, Cork, IrelandMolecular Virology Diagnostic & Research Laboratory, Department of Medicine, Clinical Sciences Building, University College Cork and Cork University Hospital, Cork, IrelandDepartment of Pharmacology and Therapeutics, Western Gateway Building, Western Road, University College Cork, Cork, Irelandp38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its contribution to both physiological and pathological conditions are presently lacking. Recent emerging evidence, however, provides some insights into specific p38δ MAPK signalling. Importantly, these studies have helped to highlight functional similarities as well as differences between p38δ MAPK and the other members of the p38 MAPK family of kinases. In this review we discuss the current understanding of the molecular mechanisms underlying p38δ MAPK activity. We outline a role for p38δ MAPK in important cellular processes such as differentiation and apoptosis as well as pathological conditions such as neurodegenerative disorders, diabetes, and inflammatory disease. Interestingly, disparate roles for p38δ MAPK in tumour development have also recently been reported. Thus, we consider evidence which characterises p38δ MAPK as both a tumour promoter and a tumour suppressor. In summary, while our knowledge of p38δ MAPK has progressed somewhat since its identification in 1997, our understanding of this particular isoform in many cellular processes still strikingly lags behind that of its counterparts.http://dx.doi.org/10.1155/2014/272689 |
| spellingShingle | Carol O’Callaghan Liam J. Fanning Orla P. Barry p38δ MAPK: Emerging Roles of a Neglected Isoform International Journal of Cell Biology |
| title | p38δ MAPK: Emerging Roles of a Neglected Isoform |
| title_full | p38δ MAPK: Emerging Roles of a Neglected Isoform |
| title_fullStr | p38δ MAPK: Emerging Roles of a Neglected Isoform |
| title_full_unstemmed | p38δ MAPK: Emerging Roles of a Neglected Isoform |
| title_short | p38δ MAPK: Emerging Roles of a Neglected Isoform |
| title_sort | p38δ mapk emerging roles of a neglected isoform |
| url | http://dx.doi.org/10.1155/2014/272689 |
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