CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA
Cardiovascular diseases caused by atherosclerosis and its complications represent the leading cause of death in developed countries. The main risk factor of atherosclerosis development is dyslipidemia, in particular familial hypercholesterolemia (FH) characterized by inherited dysregulation of lipid...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2018-12-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/124 |
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| author | OLGA L. Barbarash NATALIA V. Fedorova VASILIY V. Kashtalap ROMAN A. Kornelyuk OLESYA E. Astafurova DMITRIY L. Shukevich OLGA V. Gruzdeva |
| author_facet | OLGA L. Barbarash NATALIA V. Fedorova VASILIY V. Kashtalap ROMAN A. Kornelyuk OLESYA E. Astafurova DMITRIY L. Shukevich OLGA V. Gruzdeva |
| author_sort | OLGA L. Barbarash |
| collection | DOAJ |
| description | Cardiovascular diseases caused by atherosclerosis and its complications represent the leading cause of death in developed countries. The main risk factor of atherosclerosis development is dyslipidemia, in particular familial hypercholesterolemia (FH) characterized by inherited dysregulation of lipid metabolism. Standard medications to control dyslipidemia did not exhibit notable efficacy in patients with FH; instead novel cholesterol-lowering medications (e.g. PCSK9 inhibitors) or extracorporeal treatment such as LDL-apheresis should be applied. Here we present a clinical case of employing HELP-apheresis to treat a female patient with FH. Initially, combined therapy by maximum tolerated dose of statins and ezetimibe demonstrated little if any efficacy. Two sessions of HELP-apheresis showed high efficacy and safety rates. In addition to the main hypolipidemic effect, this method improves blood rheological properties, potentiating anti-atherogenic effects and favoring the prognosis in patients with severe lipid metabolism disorders. |
| format | Article |
| id | doaj-art-39ccd75c17674ce28d1d60e5b5cbf11c |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-39ccd75c17674ce28d1d60e5b5cbf11c2025-08-20T03:57:40ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412018-12-0134113125123CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIAOLGA L. Barbarash0NATALIA V. Fedorova1VASILIY V. Kashtalap2ROMAN A. Kornelyuk3OLESYA E. Astafurova4DMITRIY L. Shukevich5OLGA V. Gruzdeva6Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular Diseases; Barbarash Kemerovo Regional Clinical Cardiology DispensaryResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University; Barbarash Kemerovo Regional Clinical Cardiology DispensaryResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University; Barbarash Kemerovo Regional Clinical Cardiology DispensaryBarbarash Kemerovo Regional Clinical Cardiology DispensaryResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityCardiovascular diseases caused by atherosclerosis and its complications represent the leading cause of death in developed countries. The main risk factor of atherosclerosis development is dyslipidemia, in particular familial hypercholesterolemia (FH) characterized by inherited dysregulation of lipid metabolism. Standard medications to control dyslipidemia did not exhibit notable efficacy in patients with FH; instead novel cholesterol-lowering medications (e.g. PCSK9 inhibitors) or extracorporeal treatment such as LDL-apheresis should be applied. Here we present a clinical case of employing HELP-apheresis to treat a female patient with FH. Initially, combined therapy by maximum tolerated dose of statins and ezetimibe demonstrated little if any efficacy. Two sessions of HELP-apheresis showed high efficacy and safety rates. In addition to the main hypolipidemic effect, this method improves blood rheological properties, potentiating anti-atherogenic effects and favoring the prognosis in patients with severe lipid metabolism disorders.https://fcm.kemsmu.ru/jour/article/view/124дислипидемиясемейная гиперхолестеринемияhelp-аферезdyslipidemiafamilial hypercholesterolemiahelp-apheresis |
| spellingShingle | OLGA L. Barbarash NATALIA V. Fedorova VASILIY V. Kashtalap ROMAN A. Kornelyuk OLESYA E. Astafurova DMITRIY L. Shukevich OLGA V. Gruzdeva CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA Фундаментальная и клиническая медицина дислипидемия семейная гиперхолестеринемия help-аферез dyslipidemia familial hypercholesterolemia help-apheresis |
| title | CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA |
| title_full | CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA |
| title_fullStr | CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA |
| title_full_unstemmed | CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA |
| title_short | CLINICAL APPLICATION OF HELP-APHERESIS IN FEMALE PATIENT WITH FAMILIAL HYPERCHOLESTEROLEMIA |
| title_sort | clinical application of help apheresis in female patient with familial hypercholesterolemia |
| topic | дислипидемия семейная гиперхолестеринемия help-аферез dyslipidemia familial hypercholesterolemia help-apheresis |
| url | https://fcm.kemsmu.ru/jour/article/view/124 |
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