Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment

Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment

ObjectivePrevious research has demonstrated that the hypoxic environment at high altitudes significantly alters the pharmacokinetics of many drugs, reducing their efficacy and increasing adverse effects. A key factor in this altered drug metabolism is the inhibition of ATP-binding cassette subfamily...

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Bibliographic Details
Main Authors: Ziqin Wei, Hongfang Mu, Fangfang Qiu, Minghui Zhao, Xiaojing Zhang, Wenbin Li, Hai Jia, Rong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Physiology
Subjects:
hypoxia
ABCB1
HDAC inhibitor
HDAC5
Sp1
H3K9ac
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1520246/full
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