Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression
Cervical cancer (CC), which ranks among the four most common cancers in women, is a leading cause of both illness and death globally. It's urgent to identify a new biomarker to elucidate the potential mechanisms underlying the progression of CC. Here, we screened the differentially expressed ge...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024169976 |
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| author | Hai Zhu Yaping Wang Yu Zhang Yun Tian Duan Liu Xiabing Li Gaili Ji Caixia Ma Hongyu Li |
| author_facet | Hai Zhu Yaping Wang Yu Zhang Yun Tian Duan Liu Xiabing Li Gaili Ji Caixia Ma Hongyu Li |
| author_sort | Hai Zhu |
| collection | DOAJ |
| description | Cervical cancer (CC), which ranks among the four most common cancers in women, is a leading cause of both illness and death globally. It's urgent to identify a new biomarker to elucidate the potential mechanisms underlying the progression of CC. Here, we screened the differentially expressed genes (DEGs) in the Cancer Genome Atlas database (TCGA) and selected Chromosome 1 open reading frame 74 (C1orf74) for further investigation. C1orf74 levels were elevated, indicating a link to poor prognosis.Higher expression of C1orf74 was significantly related to clinical stage, T stage, histological type and survival status. Functional enrichment analysis indicated that C1orf74 is likely associated with the MAPK signaling pathway. Moreover, we found that C1orf74 was correlated with multifarious immune cell infiltration. Finally, the knockdown of C1orf74 significantly inhibited the growth of CC in vitro. In conclusion, C1orf74 promotes CC proliferation and progression, is closely associated with poor prognosis, and plays a role in the tumor immune microenvironment. The research indicates that C1orf74 is important for treating CC and may help develop new strategies to improve patient outcomes. |
| format | Article |
| id | doaj-art-39c41f649e264acf876e7e8a68e20fb1 |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-39c41f649e264acf876e7e8a68e20fb12025-08-20T01:58:31ZengElsevierHeliyon2405-84402024-12-011024e4096610.1016/j.heliyon.2024.e40966Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progressionHai Zhu0Yaping Wang1Yu Zhang2Yun Tian3Duan Liu4Xiabing Li5Gaili Ji6Caixia Ma7Hongyu Li8Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, ChinaGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China; Zhengzhou Key Laboratory of Gynecological Oncology, Zhengzhou, 450052, Henan, ChinaGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, ChinaGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China; Zhengzhou Key Laboratory of Gynecological Oncology, Zhengzhou, 450052, Henan, ChinaGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, ChinaGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, ChinaZhengzhou Key Laboratory of Gynecological Oncology, Zhengzhou, 450052, Henan, China; Department of Gynecology and Obstetrics, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, ChinaZhengzhou Key Laboratory of Gynecological Oncology, Zhengzhou, 450052, Henan, China; Department of Gynecology and Obstetrics, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, ChinaGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China; Zhengzhou Key Laboratory of Gynecological Oncology, Zhengzhou, 450052, Henan, China; Corresponding author. Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, No. 7 Kangfu Front Street, Zhengzhou, Henan, 450000, China.Cervical cancer (CC), which ranks among the four most common cancers in women, is a leading cause of both illness and death globally. It's urgent to identify a new biomarker to elucidate the potential mechanisms underlying the progression of CC. Here, we screened the differentially expressed genes (DEGs) in the Cancer Genome Atlas database (TCGA) and selected Chromosome 1 open reading frame 74 (C1orf74) for further investigation. C1orf74 levels were elevated, indicating a link to poor prognosis.Higher expression of C1orf74 was significantly related to clinical stage, T stage, histological type and survival status. Functional enrichment analysis indicated that C1orf74 is likely associated with the MAPK signaling pathway. Moreover, we found that C1orf74 was correlated with multifarious immune cell infiltration. Finally, the knockdown of C1orf74 significantly inhibited the growth of CC in vitro. In conclusion, C1orf74 promotes CC proliferation and progression, is closely associated with poor prognosis, and plays a role in the tumor immune microenvironment. The research indicates that C1orf74 is important for treating CC and may help develop new strategies to improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S2405844024169976C1orf74Cervical cancerPrognosisImmune infiltrationImmune checkpoints |
| spellingShingle | Hai Zhu Yaping Wang Yu Zhang Yun Tian Duan Liu Xiabing Li Gaili Ji Caixia Ma Hongyu Li Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression Heliyon C1orf74 Cervical cancer Prognosis Immune infiltration Immune checkpoints |
| title | Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression |
| title_full | Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression |
| title_fullStr | Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression |
| title_full_unstemmed | Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression |
| title_short | Overexpression of C1orf74 predicts poor outcome and promote cervical cancer progression |
| title_sort | overexpression of c1orf74 predicts poor outcome and promote cervical cancer progression |
| topic | C1orf74 Cervical cancer Prognosis Immune infiltration Immune checkpoints |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024169976 |
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