HDL-cholesterol confers sensitivity of immunotherapy in nasopharyngeal carcinoma via remodeling tumor-associated macrophages towards the M1 phenotype

HDL-cholesterol confers sensitivity of immunotherapy in nasopharyngeal carcinoma via remodeling tumor-associated macrophages towards the M1 phenotype

Background The sustained effectiveness of anti-programmed cell death protein-1/programmed death-ligand 1 treatment is limited to a subgroup of patients with advanced nasopharyngeal carcinoma (NPC), and the specific biomarker determining the response to immunotherapy in NPC remains uncertain.Methods...

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Main Authors: Yan Huang, Li Zhang, Ting Yang, Hongyun Zhao, Yunpeng Yang, Ting Zhou, Jianhua Zhan, Xue Bai, Fan Luo, Qun Chen, Wenjuan Ma, Jiaxin Cao, Lusha Liu, Chaozhuo Lin
Format: Article
Language:English
Published: BMJ Publishing Group 2024-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/6/e008146.full
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