Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach
The aim of the present study was to evaluate the dose of postdialysis cholecalciferol needed to maintain the 25-hydroxyvitamin D [25(OH)D] levels in the optimal range of 75–150 nmol/L. Twenty-six patients who had low baseline 25(OH)D levels (mean 27.5±14.9 nmol/L) were studied. The 25(OH)D levels we...
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Wiley
2014-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/597429 |
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| author | Eric Descombes Benoit Fellay Ould Maouloud Hemett Jean-Luc Magnin Gilbert Fellay |
| author_facet | Eric Descombes Benoit Fellay Ould Maouloud Hemett Jean-Luc Magnin Gilbert Fellay |
| author_sort | Eric Descombes |
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| description | The aim of the present study was to evaluate the dose of postdialysis cholecalciferol needed to maintain the 25-hydroxyvitamin D [25(OH)D] levels in the optimal range of 75–150 nmol/L. Twenty-six patients who had low baseline 25(OH)D levels (mean 27.5±14.9 nmol/L) were studied. The 25(OH)D levels were measured every 2 months for one year. During the first two months, all the patients received 2000 IU of cholecalciferol after each hemodialysis (=6000 IU/wk). Thereafter, the dose was individualized and adapted every 2 months by administering 1 to 6 cholecalciferol tablets (2000 IU each) per week (total weekly dose = 2000–12000 IU/wk). During cholecalciferol supplementation, the 25(OH)D concentrations rapidly increased from baseline to 140.1±28.3 nmol/L at month 6 and 95.6±20.9 nmol/L at month 12. At month twelve, 86% of the patients had 25(OH)D levels within the target range with a mean dose of 5917±4106 IU/wk of cholecalciferol; however, the amount needed to maintain these levels varied widely from 0 (n=2) to 12000 IU/wk (n=5). In conclusion, postdialysis cholecalciferol prescription is quite effective in correcting vitamin D deficiency/insufficiency, but the amount of cholecalciferol needed to maintain the 25(OH)D levels within the optimal range over the long-term varies widely among patients and must be individualized. |
| format | Article |
| id | doaj-art-39b29e3803914bcb98ecc2aed8de7a6a |
| institution | OA Journals |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Nephrology |
| spelling | doaj-art-39b29e3803914bcb98ecc2aed8de7a6a2025-08-20T02:24:08ZengWileyInternational Journal of Nephrology2090-214X2090-21582014-01-01201410.1155/2014/597429597429Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response ApproachEric Descombes0Benoit Fellay1Ould Maouloud Hemett2Jean-Luc Magnin3Gilbert Fellay4Service of Nephrology, HFR Hôpital Cantonal, 1708 Fribourg, SwitzerlandCentral Laboratory, HFR Hôpital Cantonal, 1708 Fribourg, SwitzerlandService of Nephrology, HFR Hôpital Cantonal, 1708 Fribourg, SwitzerlandCentral Laboratory, HFR Hôpital Cantonal, 1708 Fribourg, SwitzerlandService of Nephrology, HFR Hôpital Cantonal, 1708 Fribourg, SwitzerlandThe aim of the present study was to evaluate the dose of postdialysis cholecalciferol needed to maintain the 25-hydroxyvitamin D [25(OH)D] levels in the optimal range of 75–150 nmol/L. Twenty-six patients who had low baseline 25(OH)D levels (mean 27.5±14.9 nmol/L) were studied. The 25(OH)D levels were measured every 2 months for one year. During the first two months, all the patients received 2000 IU of cholecalciferol after each hemodialysis (=6000 IU/wk). Thereafter, the dose was individualized and adapted every 2 months by administering 1 to 6 cholecalciferol tablets (2000 IU each) per week (total weekly dose = 2000–12000 IU/wk). During cholecalciferol supplementation, the 25(OH)D concentrations rapidly increased from baseline to 140.1±28.3 nmol/L at month 6 and 95.6±20.9 nmol/L at month 12. At month twelve, 86% of the patients had 25(OH)D levels within the target range with a mean dose of 5917±4106 IU/wk of cholecalciferol; however, the amount needed to maintain these levels varied widely from 0 (n=2) to 12000 IU/wk (n=5). In conclusion, postdialysis cholecalciferol prescription is quite effective in correcting vitamin D deficiency/insufficiency, but the amount of cholecalciferol needed to maintain the 25(OH)D levels within the optimal range over the long-term varies widely among patients and must be individualized.http://dx.doi.org/10.1155/2014/597429 |
| spellingShingle | Eric Descombes Benoit Fellay Ould Maouloud Hemett Jean-Luc Magnin Gilbert Fellay Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach International Journal of Nephrology |
| title | Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach |
| title_full | Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach |
| title_fullStr | Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach |
| title_full_unstemmed | Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach |
| title_short | Oral Postdialysis Cholecalciferol Supplementation in Patients on Maintenance Hemodialysis: A Dose-Response Approach |
| title_sort | oral postdialysis cholecalciferol supplementation in patients on maintenance hemodialysis a dose response approach |
| url | http://dx.doi.org/10.1155/2014/597429 |
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