ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION
Aim. To study effects of ACE inhibitor perindopril on markers of endothelial dysfunction in therapy of patients with arterial hypertension (HT).Material and methods. 82 patients with HT, complicated by ischemic stroke were involved in the study. 30 patients with uncomplicated HT were included into c...
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| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1099 |
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| author | M. P. Metrova A. B. Salmina A. I. Inzhutova O. S. Bahmeteva |
| author_facet | M. P. Metrova A. B. Salmina A. I. Inzhutova O. S. Bahmeteva |
| author_sort | M. P. Metrova |
| collection | DOAJ |
| description | Aim. To study effects of ACE inhibitor perindopril on markers of endothelial dysfunction in therapy of patients with arterial hypertension (HT).Material and methods. 82 patients with HT, complicated by ischemic stroke were involved in the study. 30 patients with uncomplicated HT were included into control group. Antihypertensive therapy with perindopril (52 patients) or amlodipine (30 patients) was conducted additionally to standard neurotropic therapy in hypertensive patients with ischemic stroke. Phase-contrast microscopy and enzyme immunoassay were used for screening of endothelial dysfunction markers (blebbing, desquamated endothelial cells, membrane-liberated parts, sPECAM-1).Results. Reduction in levels of markers of endothelial dysfunction was observed among patients treated with perindopril in comparison with patients who did not receive ACE inhibitor or patients of control group. Target levels of blood pressure were reached in 96% of patients treated with perindopril. Сonclusion. ACE inhibitors in therapy patients with HT reduce endothelial dysfunction additionally to antihypertensive effect. |
| format | Article |
| id | doaj-art-39b0ff474d774b43bb7d093ecf818eb7 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-39b0ff474d774b43bb7d093ecf818eb72025-08-23T10:00:26ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0142899210.20996/1819-6446-2008-4-2-89-921098ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTIONM. P. Metrova0A. B. Salmina1A. I. Inzhutova2O. S. Bahmeteva3Krasnoyarsk State Medical AcademyKrasnoyarsk State Medical AcademyKrasnoyarsk State Medical AcademyKrasnoyarsk State Medical AcademyAim. To study effects of ACE inhibitor perindopril on markers of endothelial dysfunction in therapy of patients with arterial hypertension (HT).Material and methods. 82 patients with HT, complicated by ischemic stroke were involved in the study. 30 patients with uncomplicated HT were included into control group. Antihypertensive therapy with perindopril (52 patients) or amlodipine (30 patients) was conducted additionally to standard neurotropic therapy in hypertensive patients with ischemic stroke. Phase-contrast microscopy and enzyme immunoassay were used for screening of endothelial dysfunction markers (blebbing, desquamated endothelial cells, membrane-liberated parts, sPECAM-1).Results. Reduction in levels of markers of endothelial dysfunction was observed among patients treated with perindopril in comparison with patients who did not receive ACE inhibitor or patients of control group. Target levels of blood pressure were reached in 96% of patients treated with perindopril. Сonclusion. ACE inhibitors in therapy patients with HT reduce endothelial dysfunction additionally to antihypertensive effect.https://www.rpcardio.online/jour/article/view/1099arterial hypertensionendothelial dysfunctionace inhibitors |
| spellingShingle | M. P. Metrova A. B. Salmina A. I. Inzhutova O. S. Bahmeteva ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION Рациональная фармакотерапия в кардиологии arterial hypertension endothelial dysfunction ace inhibitors |
| title | ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION |
| title_full | ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION |
| title_fullStr | ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION |
| title_full_unstemmed | ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION |
| title_short | ACE INHIBITORS ARE RATIONAL PHARMACOTHERAPY OF ENDOTHELIAL DYSFUNCTION |
| title_sort | ace inhibitors are rational pharmacotherapy of endothelial dysfunction |
| topic | arterial hypertension endothelial dysfunction ace inhibitors |
| url | https://www.rpcardio.online/jour/article/view/1099 |
| work_keys_str_mv | AT mpmetrova aceinhibitorsarerationalpharmacotherapyofendothelialdysfunction AT absalmina aceinhibitorsarerationalpharmacotherapyofendothelialdysfunction AT aiinzhutova aceinhibitorsarerationalpharmacotherapyofendothelialdysfunction AT osbahmeteva aceinhibitorsarerationalpharmacotherapyofendothelialdysfunction |