A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring
Abstract Obstructive sleep apnea is a globally prevalent concern with significant health impacts, especially when coupled with comorbidities. Accurate detection and localization of airway obstructions are crucial for effective diagnosis and treatment, which remains a challenge for traditional sleep...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55088-y |
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| author | Jiang Shang Xiaoxiao Ma Peikai Zou Chenxiao Huang Zhechen Lao Junhan Wang Tingshu Jiang Yanzhe Fu Jiebo Li Shaoxing Zhang Ruya Li Yubo Fan |
| author_facet | Jiang Shang Xiaoxiao Ma Peikai Zou Chenxiao Huang Zhechen Lao Junhan Wang Tingshu Jiang Yanzhe Fu Jiebo Li Shaoxing Zhang Ruya Li Yubo Fan |
| author_sort | Jiang Shang |
| collection | DOAJ |
| description | Abstract Obstructive sleep apnea is a globally prevalent concern with significant health impacts, especially when coupled with comorbidities. Accurate detection and localization of airway obstructions are crucial for effective diagnosis and treatment, which remains a challenge for traditional sleep monitoring methods. Here, we report a catheter-based flexible pressure sensor array that continuously monitors soft tissue pressure in the upper airway and facilitates at the millimeter level. The sensor’s design and versatile 3D femtosecond laser fabrication process enable adaptation to diverse materials and applications. In vitro testing demonstrates high sensitivity (38.1 Ω/mmHg) and excellent stability. The sensor array effectively monitors distributed airway pressure and accurately identifies obstructions in an obstructive sleep apnea animal model. In this work, we highlight the potential of this catheter-based sensor array for long-term, continuous upper airway pressure monitoring and its prospective applications in other medical devices for pressure measurement in human body cavities. |
| format | Article |
| id | doaj-art-39a9642711534da487ec6e262b0fcbfc |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-39a9642711534da487ec6e262b0fcbfc2025-01-05T12:38:23ZengNature PortfolioNature Communications2041-17232025-01-0116111210.1038/s41467-024-55088-yA flexible catheter-based sensor array for upper airway soft tissues pressure monitoringJiang Shang0Xiaoxiao Ma1Peikai Zou2Chenxiao Huang3Zhechen Lao4Junhan Wang5Tingshu Jiang6Yanzhe Fu7Jiebo Li8Shaoxing Zhang9Ruya Li10Yubo Fan11The Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityDepartment of Respiratory and Critical Care Medicine, Yantai Yuhuangding Hospital, affiliated with the Medical College of Qingdao UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityDepartment of Otolaryngology, Peking University Third HospitalThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityThe Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang UniversityAbstract Obstructive sleep apnea is a globally prevalent concern with significant health impacts, especially when coupled with comorbidities. Accurate detection and localization of airway obstructions are crucial for effective diagnosis and treatment, which remains a challenge for traditional sleep monitoring methods. Here, we report a catheter-based flexible pressure sensor array that continuously monitors soft tissue pressure in the upper airway and facilitates at the millimeter level. The sensor’s design and versatile 3D femtosecond laser fabrication process enable adaptation to diverse materials and applications. In vitro testing demonstrates high sensitivity (38.1 Ω/mmHg) and excellent stability. The sensor array effectively monitors distributed airway pressure and accurately identifies obstructions in an obstructive sleep apnea animal model. In this work, we highlight the potential of this catheter-based sensor array for long-term, continuous upper airway pressure monitoring and its prospective applications in other medical devices for pressure measurement in human body cavities.https://doi.org/10.1038/s41467-024-55088-y |
| spellingShingle | Jiang Shang Xiaoxiao Ma Peikai Zou Chenxiao Huang Zhechen Lao Junhan Wang Tingshu Jiang Yanzhe Fu Jiebo Li Shaoxing Zhang Ruya Li Yubo Fan A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring Nature Communications |
| title | A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring |
| title_full | A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring |
| title_fullStr | A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring |
| title_full_unstemmed | A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring |
| title_short | A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring |
| title_sort | flexible catheter based sensor array for upper airway soft tissues pressure monitoring |
| url | https://doi.org/10.1038/s41467-024-55088-y |
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