Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?
The aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic childr...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/19724 |
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| author | Grazyna Deja Przemyslawa Jarosz-Chobot Joanna Polanska Urszula Siekiera Ewa Malecka-Tendera |
| author_facet | Grazyna Deja Przemyslawa Jarosz-Chobot Joanna Polanska Urszula Siekiera Ewa Malecka-Tendera |
| author_sort | Grazyna Deja |
| collection | DOAJ |
| description | The aim of the study was to assess chosen factors of genetic
susceptibility to DMT1: DRB1, DQB1, and TNF-α
polymorphisms-308 (G/A) in children with DMT1 and their up-to-now
healthy siblings. Then we tested whether the association between
TNF-α genes and DMT1 is independent of HLA. 87 diabetic
children, their 78 siblings, and 85 persons from healthy control
group were followed up. The highest risk of DMT1 was connected
with alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41),
DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR =
4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI: 2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI: 1.23–5.44). Moreover linkage disequilibrium for TNF-α-308 A allele with DRB1*0301 and DQB1*0201 was observed in both diabetic children and their siblings. Diabetic children and
their siblings present similar genetic risk factors for DMT1. The association between TNF-α-308 A allele and DMT1 is dependent of HLA-DRB1 and DQB1 alleles. |
| format | Article |
| id | doaj-art-39a94a47b00845b996cb0dce5d94bcfd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-39a94a47b00845b996cb0dce5d94bcfd2025-02-03T01:26:02ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/1972419724Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?Grazyna Deja0Przemyslawa Jarosz-Chobot1Joanna Polanska2Urszula Siekiera3Ewa Malecka-Tendera4Department of Pediatrics, Endocrinology, and Diabetes, Medical University of Silesia, Katowice 40-752, PolandDepartment of Pediatrics, Endocrinology, and Diabetes, Medical University of Silesia, Katowice 40-752, PolandFaculty of Automatic Control, Electronic and Computer Science, Silesian University of Technology, Gilwice 44-101, PolandBlood Center, Katowice 40-074, PolandDepartment of Pediatrics, Endocrinology, and Diabetes, Medical University of Silesia, Katowice 40-752, PolandThe aim of the study was to assess chosen factors of genetic susceptibility to DMT1: DRB1, DQB1, and TNF-α polymorphisms-308 (G/A) in children with DMT1 and their up-to-now healthy siblings. Then we tested whether the association between TNF-α genes and DMT1 is independent of HLA. 87 diabetic children, their 78 siblings, and 85 persons from healthy control group were followed up. The highest risk of DMT1 was connected with alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41), DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR = 4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI: 2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI: 1.23–5.44). Moreover linkage disequilibrium for TNF-α-308 A allele with DRB1*0301 and DQB1*0201 was observed in both diabetic children and their siblings. Diabetic children and their siblings present similar genetic risk factors for DMT1. The association between TNF-α-308 A allele and DMT1 is dependent of HLA-DRB1 and DQB1 alleles.http://dx.doi.org/10.1155/MI/2006/19724 |
| spellingShingle | Grazyna Deja Przemyslawa Jarosz-Chobot Joanna Polanska Urszula Siekiera Ewa Malecka-Tendera Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? Mediators of Inflammation |
| title | Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? |
| title_full | Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? |
| title_fullStr | Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? |
| title_full_unstemmed | Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? |
| title_short | Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? |
| title_sort | is the association between tnf α 308 a allele and dmt1 independent of hla drb1 dqb1 alleles |
| url | http://dx.doi.org/10.1155/MI/2006/19724 |
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