The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses
Gonorrhoea is currently one of the most important sexually transmitted infections (STIs) due to the increasing spread of multidrug-resistant strains of N. gonorrhoeae. The aim of this study was to analyse the association between resistance or decreased susceptibility to antibiotics in N. gonorrhoeae...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1414330/full |
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| author | Ana Clara Mendes Renan Pedra de Souza Diana Bahia |
| author_facet | Ana Clara Mendes Renan Pedra de Souza Diana Bahia |
| author_sort | Ana Clara Mendes |
| collection | DOAJ |
| description | Gonorrhoea is currently one of the most important sexually transmitted infections (STIs) due to the increasing spread of multidrug-resistant strains of N. gonorrhoeae. The aim of this study was to analyse the association between resistance or decreased susceptibility to antibiotics in N. gonorrhoeae and the presence of mutations in the penA, mtrR, gyrA and parC genes, and the presence of tetM gene. We conducted a systematic review according to the PRISMA guidelines. We selected 19 studies for the penA gene, 23 for gyrA and parC, 18 for mtrR and 12 for tetM using the Science Direct and PubMed databases. Meta-analyses of isolates resistant to penicillin, cefixime and ceftriaxone showed that more than 50% of isolates had mutations in the penA and mtrR genes. More than 50% of azithromycin-resistant isolates had mutations in the mtrR gene, while more than 50% of ciprofloxacin-resistant and intermediate-resistant isolates had mutations in gyrA. Less than 50% of the isolates with intermediate resistance to ciprofloxacin had mutations in parC. The plasmid containing the tetM gene was found in more than 50% of tetracycline-resistant isolates. Infection surveillance and genetic studies are important for controlling the spread of the disease, which can improve the quality of life of infected people and reduce the financial burden on public health systems. |
| format | Article |
| id | doaj-art-39a8cac7c0314f7e8302c28173669c4c |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-39a8cac7c0314f7e8302c28173669c4c2025-01-27T13:28:18ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011510.3389/fmicb.2024.14143301414330The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analysesAna Clara MendesRenan Pedra de SouzaDiana BahiaGonorrhoea is currently one of the most important sexually transmitted infections (STIs) due to the increasing spread of multidrug-resistant strains of N. gonorrhoeae. The aim of this study was to analyse the association between resistance or decreased susceptibility to antibiotics in N. gonorrhoeae and the presence of mutations in the penA, mtrR, gyrA and parC genes, and the presence of tetM gene. We conducted a systematic review according to the PRISMA guidelines. We selected 19 studies for the penA gene, 23 for gyrA and parC, 18 for mtrR and 12 for tetM using the Science Direct and PubMed databases. Meta-analyses of isolates resistant to penicillin, cefixime and ceftriaxone showed that more than 50% of isolates had mutations in the penA and mtrR genes. More than 50% of azithromycin-resistant isolates had mutations in the mtrR gene, while more than 50% of ciprofloxacin-resistant and intermediate-resistant isolates had mutations in gyrA. Less than 50% of the isolates with intermediate resistance to ciprofloxacin had mutations in parC. The plasmid containing the tetM gene was found in more than 50% of tetracycline-resistant isolates. Infection surveillance and genetic studies are important for controlling the spread of the disease, which can improve the quality of life of infected people and reduce the financial burden on public health systems.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1414330/fullNeisseria gonorrhoeaeantibiotic resistancemutationpenAmtrRtetM |
| spellingShingle | Ana Clara Mendes Renan Pedra de Souza Diana Bahia The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses Frontiers in Microbiology Neisseria gonorrhoeae antibiotic resistance mutation penA mtrR tetM |
| title | The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses |
| title_full | The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses |
| title_fullStr | The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses |
| title_full_unstemmed | The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses |
| title_short | The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses |
| title_sort | frequency of mutations in the pena mtrr gyra and parc genes of neisseria gonorrhoeae the presence of tetm gene and antibiotic resistance susceptibility a systematic review and meta analyses |
| topic | Neisseria gonorrhoeae antibiotic resistance mutation penA mtrR tetM |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1414330/full |
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