Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx
Abstract We investigated the long-term kidney and cardiovascular outcomes of patients with chronic kidney disease (CKD) after COVID-19. Our retrospective cohort consisted of 834 CKD patients with COVID-19 and 6,167 CKD patients without COVID-19 between 3/11/2020 to 7/1/2023. Multivariate competing r...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-90153-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849723937084145664 |
|---|---|
| author | Jason Y. Lu Justin Y. Lu Stephen Wang Katie S. Duong Sonya Henry Molly C. Fisher Tim Q. Duong |
| author_facet | Jason Y. Lu Justin Y. Lu Stephen Wang Katie S. Duong Sonya Henry Molly C. Fisher Tim Q. Duong |
| author_sort | Jason Y. Lu |
| collection | DOAJ |
| description | Abstract We investigated the long-term kidney and cardiovascular outcomes of patients with chronic kidney disease (CKD) after COVID-19. Our retrospective cohort consisted of 834 CKD patients with COVID-19 and 6,167 CKD patients without COVID-19 between 3/11/2020 to 7/1/2023. Multivariate competing risk regression models were used to estimate risk (as adjusted hazard ratios (aHR) with 95% confidence intervals (CI)) of CKD progression to a more advanced stage (Stage 4 or 5) and major adverse kidney events (MAKE), and risk of major adverse cardiovascular events (MACE) at 6-, 12-, and 24-month follow up. Hospitalized COVID-19 patients at 12 and 24 months (aHR 1.62 95% CI[1.24,2.13] and 1.76 [1.30, 2.40], respectively), but not non-hospitalized COVID-19 patients, were at higher risk of CKD progression compared to those without COVID-19. Both hospitalized and non-hospitalized COVID-19 patients were at higher risk of MAKE at 6-, 12- and 24-months compared to those without COVID-19. Hospitalized COVID-19 patients at 6-, 12- and 24-months (aHR 1.73 [1.21, 2.50], 1.77 [1.34, 2.33], and 1.31 [1.05, 1.64], respectively), but not non-hospitalized COVID-19 patients, were at higher risk of MACE compared to those without COVID-19. COVID-19 increases the risk of long-term CKD progression and cardiovascular events in patients with CKD. These findings highlight the need for close follow up care and therapies that slow CKD progression in this high-risk subgroup. |
| format | Article |
| id | doaj-art-39a528f7d97d426aaef45c1080fb6a5a |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-39a528f7d97d426aaef45c1080fb6a5a2025-08-20T03:10:53ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-90153-6Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the BronxJason Y. Lu0Justin Y. Lu1Stephen Wang2Katie S. Duong3Sonya Henry4Molly C. Fisher5Tim Q. Duong6Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Medicine, Nephrology Division, Albert Einstein College of MedicineDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterAbstract We investigated the long-term kidney and cardiovascular outcomes of patients with chronic kidney disease (CKD) after COVID-19. Our retrospective cohort consisted of 834 CKD patients with COVID-19 and 6,167 CKD patients without COVID-19 between 3/11/2020 to 7/1/2023. Multivariate competing risk regression models were used to estimate risk (as adjusted hazard ratios (aHR) with 95% confidence intervals (CI)) of CKD progression to a more advanced stage (Stage 4 or 5) and major adverse kidney events (MAKE), and risk of major adverse cardiovascular events (MACE) at 6-, 12-, and 24-month follow up. Hospitalized COVID-19 patients at 12 and 24 months (aHR 1.62 95% CI[1.24,2.13] and 1.76 [1.30, 2.40], respectively), but not non-hospitalized COVID-19 patients, were at higher risk of CKD progression compared to those without COVID-19. Both hospitalized and non-hospitalized COVID-19 patients were at higher risk of MAKE at 6-, 12- and 24-months compared to those without COVID-19. Hospitalized COVID-19 patients at 6-, 12- and 24-months (aHR 1.73 [1.21, 2.50], 1.77 [1.34, 2.33], and 1.31 [1.05, 1.64], respectively), but not non-hospitalized COVID-19 patients, were at higher risk of MACE compared to those without COVID-19. COVID-19 increases the risk of long-term CKD progression and cardiovascular events in patients with CKD. These findings highlight the need for close follow up care and therapies that slow CKD progression in this high-risk subgroup.https://doi.org/10.1038/s41598-025-90153-6Long covidPost-acute sequela of COVID-19 (PASC)Kidney disordersCreatinineEGFRDialysis |
| spellingShingle | Jason Y. Lu Justin Y. Lu Stephen Wang Katie S. Duong Sonya Henry Molly C. Fisher Tim Q. Duong Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx Scientific Reports Long covid Post-acute sequela of COVID-19 (PASC) Kidney disorders Creatinine EGFR Dialysis |
| title | Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx |
| title_full | Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx |
| title_fullStr | Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx |
| title_full_unstemmed | Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx |
| title_short | Long term outcomes of patients with chronic kidney disease after COVID-19 in an urban population in the Bronx |
| title_sort | long term outcomes of patients with chronic kidney disease after covid 19 in an urban population in the bronx |
| topic | Long covid Post-acute sequela of COVID-19 (PASC) Kidney disorders Creatinine EGFR Dialysis |
| url | https://doi.org/10.1038/s41598-025-90153-6 |
| work_keys_str_mv | AT jasonylu longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx AT justinylu longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx AT stephenwang longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx AT katiesduong longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx AT sonyahenry longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx AT mollycfisher longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx AT timqduong longtermoutcomesofpatientswithchronickidneydiseaseaftercovid19inanurbanpopulationinthebronx |