A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway

Streptococcus equi subsp. zooepidemicus (SEZ) is a major equine pathogen that causes pneumonia, abortion, and polyarthritis. It can also cause invasive infections in humans. SEZ expresses the M-like protein SzM, which recruits host proteins such as fibrinogen to the bacterial surface. Equine SEZ str...

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Bibliographic Details
Main Authors: René Bergmann, Wieland Schroedl, Uwe Müller, Christoph Georg Baums
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Virulence
Subjects:
Streptococcus equi subsp. zooepidemicus
complement system
C1q
M-like protein SzM
C3b deposition
complement evasion
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2023.2235461
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